GOLPH4 Activators
Chemical activators of GOLIM4 encompass a range of compounds that exert their influence through the modulation of cellular stress responses and the integrity of the Golgi apparatus. These chemicals typically elicit a cellular compensatory mechanism to restore homeostasis, which can lead to the increased expression or stabilization of Golgi-associated proteins, including GOLIM4. For example, agents that induce endoplasmic reticulum (ER) stress, such as Thapsigargin and Tunicamycin, trigger a broad upregulation of protein folding and trafficking machinery. The cell's efforts to manage the ER stress could lead to a secondary upregulation of GOLIM4, facilitating its role in protein processing.
Forskolin and other signaling pathway modulators like curcumin affect various aspects of cellular metabolism and protein synthesis, which can lead to changes in the expression of Golgi proteins. Additionally, agents like 17-AAG and Celastrol, which modulate the heat shock response, could enhance the cellular folding capacity, including the potential upregulation of GOLIM4. Proteasome inhibitors such as MG132 increase the levels of misfolded proteins within the cell, demanding enhanced protein processing capabilities, which may lead to a greater reliance on GOLIM4 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Elevates intracellular cAMP levels, which can enhance the protein synthesis machinery and potentially upregulate proteins involved in Golgi function, including GOLIM4. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
An Hsp90 inhibitor that can lead to the stabilization of client proteins and enhancement of cellular stress responses, potentially increasing the expression of Golgi proteins such as GOLIM4. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Induces ER stress, which can lead to a global upregulation of protein folding machinery, including potentially GOLIM4, as the cell attempts to mitigate the unfolded protein response. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that may lead to the accumulation of misfolded proteins, triggering cellular responses to manage protein load, which can include the upregulation of Golgi-associated proteins like GOLIM4. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Induces ER stress and impairs N-linked glycosylation, potentially enhancing the cellular machinery for protein folding and trafficking, including GOLIM4 as a compensatory response. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Can induce a cellular stress response, which may enhance the expression of Golgi-associated proteins, including GOLIM4, to handle increased stress on protein trafficking pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Has been shown to affect multiple signaling pathways and could modulate the expression of proteins involved in the secretory pathway, potentially leading to an increase in GOLIM4 expression. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Induces heat shock response and could potentially enhance the expression of proteins involved in the folding and trafficking of Golgi proteins, such as GOLIM4. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
A glycolysis inhibitor that induces cellular stress responses, potentially increasing the expression of proteins that assist in managing protein folding and trafficking, including GOLIM4. | ||||||