GOLGA8A Inhibitors
GOLGA8A inhibitors are a class of chemical compounds that specifically target and inhibit the function of the Golgin A8 family member A (GOLGA8A) protein. GOLGA8A is associated with the Golgi apparatus, a critical organelle involved in protein processing, trafficking, and glycosylation. By inhibiting GOLGA8A, these compounds disrupt its normal role in maintaining the structural integrity of the Golgi and its involvement in intracellular transport mechanisms. This disruption can lead to changes in Golgi dynamics and the mislocalization of proteins, affecting the cellular machinery responsible for processing and sorting proteins and lipids.
The mode of action of GOLGA8A inhibitors may involve binding to the GOLGA8A protein directly, preventing its interaction with other components of the Golgi apparatus or impairing its structural scaffolding functions. These inhibitors provide a useful tool in understanding the molecular mechanisms that underlie Golgi organization and its contribution to cellular processes such as protein secretion and membrane transport. As research tools, GOLGA8A inhibitors enable scientists to probe the functional role of this protein in cellular homeostasis and Golgi-mediated trafficking. The study of these inhibitors also helps to explore how disruptions in Golgi apparatus function might affect cellular physiology, particularly in processes that are heavily dependent on protein and lipid trafficking.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $199.00 $599.00 | 24 | |
GW4869 is a neutral sphingomyelinase (nSMase) inhibitor. GOLGA8A is associated with vesicular transport and membrane trafficking. Inhibition of nSMase by GW4869 impedes ceramide production, thus potentially disrupting the membrane dynamics necessary for GOLGA8A's vesicle trafficking function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A is an inhibitor of ADP-ribosylation factor (ARF), a small GTPase involved in vesicle formation in the Golgi apparatus. As GOLGA8A is implicated in Golgi apparatus structure and function, inhibiting ARF with Brefeldin A could disrupt the regular assembly and maintenance of Golgi stacks, indirectly inhibiting GOLGA8A activity. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 is a potent and selective inhibitor of Cdc42, a small GTPase involved in cytoskeletal organization. GOLGA8A, through its interaction with the cytoskeleton, may be indirectly affected by ML141, as altered cytoskeletal dynamics can influence Golgi apparatus positioning and function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a GTPase inhibitor of dynamin, which is involved in membrane fission during vesicle trafficking. By inhibiting dynamin, Dynasore could impair vesicle release from the Golgi, where GOLGA8A functions, thus indirectly decreasing GOLGA8A-mediated vesicle trafficking. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D disrupts actin polymerization, affecting cytoskeletal structure. Since GOLGA8A is involved in maintaining Golgi structure, which is dependent on the actin cytoskeleton, this compound could indirectly inhibit GOLGA8A by destabilizing Golgi integrity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a microtubule depolymerizer. GOLGA8A's role in vesicle transport and Golgi organization could be indirectly inhibited by nocodazole as it disrupts microtubule networks, which are essential for vesicle movement towards the Golgi apparatus. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $187.00 $670.00 | 11 | |
Golgicide A is a specific inhibitor of the Golgi BFA resistance factor 1 (GBF1), a GEF for Arf1. By inhibiting GBF1, Golgicide A disrupts ARF-mediated Golgi trafficking and could thereby indirectly inhibit GOLGA8A by impairing proper Golgi function and maintenance. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
SecinH3 is an inhibitor of cytohesins, which are ARF GTPase exchange factors. By inhibiting cytohesins, SecinH3 can disrupt ARF-dependent regulation of vesicle trafficking, potentially leading to an indirect inhibition of GOLGA8A by affecting its role in Golgi apparatus dynamics. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal is a selective inhibitor of phosphatases that dephosphorylate eIF2α. Inhibition of eIF2α dephosphorylation leads to a general attenuation of protein translation. Given GOLGA8A is a Golgi-associated protein, its function could be indirectly reduced due to lower levels of protein synthesis, affecting the Golgi apparatus and vesicle trafficking. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts Golgi function by altering pH and cation homeostasis. This disruption can indirectly inhibit GOLGA8A by affecting the environment necessary for its proper function within the Golgi apparatus. | ||||||