GOLGA8A Activators
GOLGA8A activators are a category of chemical agents that primarily interact with the GOLGA8A gene product, a protein involved in the complex cellular machinery. GOLGA8A stands for 'golgin A8 family member A' and belongs to the golgin family of proteins, which are characterized by their coiled-coil regions and are known to play significant roles in the maintenance of the Golgi apparatus structure and function. The Golgi apparatus is a critical organelle in the cell that is responsible for modifying, sorting, and packaging proteins and lipids for cell secretion or use within the cell. The exact molecular function of GOLGA8A remains an active area of research, but like other golgins, it is believed to be involved in the tethering of vesicles to the Golgi membrane and in the maintenance of Golgi structural integrity, which is crucial for its role in processing cellular materials.
Activators in this chemical class specifically target the pathways or interactions that regulate the expression or function of GOLGA8A. By binding to the protein or influencing the gene expression at the transcriptional level, these activators can modulate the activity of GOLGA8A. The modulation of GOLGA8A activity can lead to alterations in the Golgi apparatus, which, due to its central role in trafficking and protein processing, may affect various intracellular processes. The mechanism of action for these activators may involve direct binding to GOLGA8A or its associated molecules, or it could entail indirect effects through upstream signaling pathways that converge on the regulation of GOLGA8A expression or stability. The fine-tuning of GOLGA8A activity by these activators is of considerable interest in the study of intracellular transport and the cell's secretory pathway, given the importance of these processes in maintaining cellular homeostasis and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can lead to the activation of PKA. The activated PKA can then phosphorylate various proteins, including those involved in the Golgi apparatus function. GOLGA8A, as a golgin tethering protein, may have its function enhanced due to the changes in the Golgi structure and trafficking efficiency caused by PKA activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC) which is involved in various cell signaling pathways, including those that regulate the cytoskeleton and vesicular transport. PKC activation may therefore enhance the function of GOLGA8A by promoting its role in Golgi apparatus structure and membrane traffic. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine activates adenosine receptors, which can influence intracellular cAMP levels. This can indirectly enhance GOLGA8A function by modulating Golgi apparatus dynamics through cAMP-dependent pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Ionophore A23187 increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. These pathways might enhance GOLGA8A function by influencing Golgi apparatus morphology and trafficking. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain protein kinases, which can alter signal transduction pathways that regulate Golgi apparatus dynamics. This may lead to an indirect enhancement of GOLGA8A function by modulating the phosphorylation state of proteins involved in Golgi structure and trafficking. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the structure of the Golgi apparatus by inhibiting ARF, a small GTPase. This disruption can result in a compensatory enhancement of GOLGA8A function to maintain Golgi integrity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubules, which are essential for Golgi apparatus positioning and function. The subsequent cellular response to re-establish Golgi integrity could lead to the enhancement of GOLGA8A activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, a kinase involved in many signaling pathways, including those affecting the Golgi apparatus. Inhibition of PI3K can enhance GOLGA8A function by modulating vesicular trafficking processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. Similar to LY294002, it may enhance GOLGA8A function by affecting the vesicular trafficking pathways that involve the Golgi apparatus. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. By altering the phosphorylation state of cellular proteins, it may indirectly enhance GOLGA8A activity, as GOLGA8A's function is modulated by phosphorylation. | ||||||