Gm428 Activators
Chemicals that act as Myb/SANT DNA binding domain containing 5 family member 1 activators function through a variety of mechanisms, but all converge on the enhancement of MSANTD5F1's functional activity. Forskolin, Isoproterenol, IBMX, and Dibutyryl cAMP all serve to increase intracellular cAMP levels, activating PKA, which can then phosphorylate various substrates including transcription factors that regulate MSANTD5F1 activity. Elevated cAMP levels can also have a cascading effect on other signaling pathways that indirectly influence the activity of MSANTD5F1. Further, PMA and Ionomycin act on the PKC and calcium signaling pathways, respectively. PMA enhances PKC activity which modulates the function of transcription factors and coactivators that can interact with MSANTD5F1, potentially leading to its increased activity. Ionomycin, by increasing intracellular calcium, activates calmodulin and calcium/calmodulin-dependent protein kinases that could similarly influence the regulatory proteins of MSANTD5F1. EGCG and Resveratrol modulate DNA methylation and SIRT1 activity, respectively, which can lead to alterations in chromatin structure, thereby influencing the transcriptional activity ofgenes including MSANTD5F1.
Sodium butyrate and Retinoic acid are involved in the epigenetic regulation of gene expression. Sodium butyrate, as a histone deacetylase inhibitor, leads to a more open chromatin structure, thereby potentially enhancing the transcription of MSANTD5F1, while Retinoic acid, through its activation of retinoic acid receptors, can also modulate gene expression patterns favorably for MSANTD5F1 activity. Curcumin's modulation of the NF-κB pathway, which is a key regulator of immune response and cell survival, can also lead to the enhanced transcription of genes that are co-regulated with MSANTD5F1, hence indirectly increasing its activity. LY294002, by inhibiting PI3K, alters AKT signaling which can impact the activity of various transcription factors and cellular proteins that may be involved in the regulation of MSANTD5F1, consequently enhancing its function.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP enhances PKA activity which can lead to phosphorylation and activation of transcription factors that could interact with the regulatory regions of MSANTD5F1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which can modulate transcription factors and coactivators that may interact with MSANTD5F1 to enhance its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium concentration, which can activate calmodulin and calcium/calmodulin-dependent protein kinases, potentially influencing factors that regulate MSANTD5F1 activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Beta-adrenergic agonist that increases cAMP levels, thereby activating PKA which may lead to changes in phosphorylation status of proteins that modulate MSANTD5F1 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-specific inhibitor of phosphodiesterases, which prevents cAMP degradation, potentially enhancing pathways that regulate MSANTD5F1 through PKA activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Inhibits DNA methyltransferases, which could lead to demethylation of the MSANTD5F1 promoter, enhancing its expression and thus its activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Activates SIRT1, which can deacetylate histones and transcription factors, potentially modulating the chromatin structure and transcription factor activity to enhance MSANTD5F1 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Modulates NF-κB pathway, which is involved in the regulation of gene expression. This modulation may enhance the transcription of genes including those that regulate MSANTD5F1 activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Histone deacetylase inhibitor which leads to a more relaxed chromatin state and can enhance transcription of genes, possibly including MSANTD5F1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Activates retinoic acid receptors which can modulate gene expression, potentially increasing the activity of MSANTD5F1 through enhanced transcription of its regulatory elements. | ||||||