Gm355 Activators
Speedy/RINGO cell cycle regulator family member E4C activators, commonly referred to as Spdye4c Activators, are a unique class of chemical compounds that affect cell cycle regulation through various molecular mechanisms. These activators interact with intracellular signaling pathways to modulate the activity of the Spdye4c protein, a key player in regulating the cell cycle's progression. The primary mode of action for many compounds within this class is to influence the levels of cyclic adenosine monophosphate (cAMP) within the cell. Agents such as Forskolin, Rolipram, and IBMX work by either directly activating adenylyl cyclase or inhibiting the breakdown of cAMP, resulting in increased intracellular concentrations. This elevation in cAMP triggers the activation of protein kinase A (PKA), an enzyme that phosphorylates various target proteins, a process that is closely tied to the regulation of the cell cycle. By enhancing the phosphorylation status of these proteins, Spdye4c Activators indirectly modulate the activity of the Spdye4c protein, which plays a pivotal role in cell cycle checkpoints.
Beyond the cAMP-PKA signaling axis, other members of the Spdye4c Activators class operate through different biochemical pathways. Compounds like Epigallocatechin gallate, Resveratrol, and Curcumin, for example, exert their effects by modulating kinase activity and influencing transcription factors. These activities result in alterations to the phosphorylation landscape of the cell, affecting proteins that interact with the cell cycle machinery. Additionally, compounds such as Retinoic acid and Trichostatin A impact gene expression and chromatin structure, respectively, leading to changes in the expression and function of proteins critical to cell cycle regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, leading to increased cAMP levels in cells, which activates PKA. PKA phosphorylation targets may interact with Speedy/RINGO cell cycle regulator family, member E4C, thus promoting its cell cycle regulatory functions. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterase which increases cAMP levels, thereby activating PKA. This can enhance the activity of Speedy/RINGO cell cycle regulator family, member E4C through phosphorylation mechanisms. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been shown to modulate activity of various kinases and could enhance the phosphorylation status of proteins involved in cell cycle regulation, potentially affecting Speedy/RINGO cell cycle regulator family, member E4C activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which can deacetylate proteins linked to cell cycle control, possibly enhancing the function of Speedy/RINGO cell cycle regulator family, member E4C in cell cycle progression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can activate various kinases and modulate transcription factors related to cell cycle progression, which may lead to an enhanced activity of Speedy/RINGO cell cycle regulator family, member E4C. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, causing an increase in cAMP levels and activation of PKA, which could enhance the activity of Speedy/RINGO cell cycle regulator family, member E4C by influencing proteins involved in the cell cycle. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences cell cycle progression by modulating the activity of cell cycle-related proteins, potentially enhancing the function of Speedy/RINGO cell cycle regulator family, member E4C. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is an HDAC inhibitor which alters the acetylation status of histones and non-histone proteins, potentially enhancing the activity of Speedy/RINGO cell cycle regulator family, member E4C by modulation of the chromatin structure related to cell cycle gene expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which may lead to altered activity of downstream kinases involved in cell cycle progression, indirectly enhancing the function of Speedy/RINGO cell cycle regulator family, member E4C. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an MEK inhibitor, which may alter the MAPK signaling pathway. Changes in this pathway could influence the activity of Speedy/RINGO cell cycle regulator family, member E4C by affecting the phosphorylation of proteins involved in cell cycle control. | ||||||