Gm1337 Activators
Ankyrin repeat domain 63 activators engage in a diverse array of cellular mechanisms to enhance the functional activity of the protein. Compounds such as Phorbol Myristate Acetate (PMA) and Forskolin activate protein kinase C (PKC) and protein kinase A (PKA), respectively, which are enzymes capable of phosphorylating numerous proteins within the cell. The phosphorylation events induced by these kinases can lead to the activation of ankyrin repeat domain 63 by direct modification or through a cascade of interactions within the signaling network. Similarly, Ionomycin, by raising intracellular calcium levels, can activate calcium-dependent kinases that may phosphorylate or cause conformational changes in ankyrin repeat domain 63, thus enhancing its activity. Compounds such as Epigallocatechin Gallate (EGCG) and Curcumin can alter kinase signaling by inhibiting tyrosine kinases or NF-κB, respectively, leading to changes in cellular signaling cascades that may result in the activation of ankyrin repeat domain 63.
Moreover, activators such as Resveratrol can enhance the activity of ankyrin repeat domain 63 indirectly via the activation of sirtuins, which deacetylate proteins affecting their function. Inhibitors of key signaling pathways, such as LY294002 (PI3K inhibitor), SB203580 (p38 MAPK inhibitor), U0126 (MEK inhibitor), and Rapamycin (mTOR inhibitor), can induce compensatory cellular responses that may include the activation of ankyrin repeat domain 63. These compounds affect major regulatory pathways and can result in a reprogramming of cellular activities that enhances the function of ankyrin repeat domain 63. AICAR, an AMPK activator, stimulates a master regulatory kinase involved in energy homeostasis, which could enhance ankyrin repeat domain 63 activity through metabolic pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). PKC, in turn, can phosphorylate a multitude of proteins, potentially including ankyrin repeat domain 63, leading to its activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing intracellular cAMP levels, which activates PKA. PKA can phosphorylate various substrates that may interact with and enhance the activity of ankyrin repeat domain 63. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium can activate calmodulin-dependent protein kinases, which may influence ankyrin repeat domain 63 function through phosphorylation or conformational changes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several protein tyrosine kinases, potentially altering signaling cascades that converge on ankyrin repeat domain 63, leading to its activation by relieving negative regulatory controls. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cAMP analog that activates PKA. PKA then phosphorylates target proteins, which may include ankyrin repeat domain 63, resulting in its activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB activation, which can lead to the alteration of downstream signaling pathways that may involve ankyrin repeat domain 63, potentially enhancing its activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuins, particularly SIRT1, which can deacetylate proteins and affect their function. SIRT1 may modulate proteins that interact with or regulate ankyrin repeat domain 63, thereby enhancing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor which alters the AKT signaling pathway. Inhibition of this pathway can lead to compensatory cellular responses that may include the activation of ankyrin repeat domain 63. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that may perturb the MAPK signaling pathway, resulting in altered signaling dynamics that could activate ankyrin repeat domain 63. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, a kinase in the MAPK/ERK pathway. Inhibition of this pathway can lead to compensatory cellular responses that enhance the activity of ankyrin repeat domain 63. | ||||||