Glut5 Inhibitors
Glut5 inhibitors include compounds that exert their influence through a variety of mechanisms to impede the activity of Glut5, a transporter protein primarily responsible for the uptake of fructose into cells. These inhibitors can work directly by binding to the transporter and blocking its fructose transport capacity, or indirectly by affecting the cellular signaling pathways that regulate the expression and trafficking of Glut5. Direct inhibition is characterized by a competitive or non-competitive blockade of the fructose binding site, which physically obstructs fructose from entering the cell via Glut5.
Indirect inhibitors, meanwhile, act through secondary mechanisms that ultimately downregulate or impair the function of Glut5. For instance, some inhibitors may impact the energy metabolism within the cell, altering the need and availability of fructose transport. Others may influence the insulin signaling pathway, which is known to regulate the abundance and activity of various glucose transporters, extending to Glut5. Additionally, certain compounds may inhibit kinases or other proteins involved in the post-translational modification of Glut5, thereby affecting its trafficking to the plasma membrane where it carries out its function. These inhibitors are not exclusively selective for Glut5 and may affect other transporters or cellular processes due to the interconnected nature of metabolic pathways. Their effectiveness can vary widely, depending on the cellular context, such as the type of cell, the presence of other sugars, and the overall metabolic state. Nonetheless, these compounds provide valuable tools for modulating fructose transport and studying the role of Glut5 in cellular metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $63.00 $250.00 | 13 | |
Phloretin, a dihydrochalcone compound found in apples, inhibits Glut5 by binding to the glucose transport pathway, thus reducing fructose transport across the membrane. This competitive inhibition directly affects the transporter's ability to facilitate the passage of fructose, thereby decreasing fructose uptake. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Wiskostatin is a small molecule inhibitor that can inhibit glucose transporters. Although its primary target is Glut1, it can also reduce fructose uptake indirectly by modulating the glycolytic pathway, affecting energy metabolism and leading to a decrease in Glut5 transporter expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone from soy products, acts as a tyrosine kinase inhibitor. By altering the phosphorylation state of proteins, it may indirectly lead to modifications in Glut5 trafficking to the cell membrane, reducing the transporter's presence and function. | ||||||
STF 31 | 724741-75-7 | sc-364692 | 10 mg | $183.00 | 3 | |
STF-31 is known to inhibit glucose uptake by targeting Glut1. Its structural action may also disturb the glucose transport pathway which has similarities with Glut5, possibly leading to reduced fructose transport. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that has been shown to inhibit the transport function of Glut2. It could extend its inhibitory effects to Glut5, affecting fructose uptake due to the structural similarities between these transporters. | ||||||
Cytochalasin B | 14930-96-2 | sc-3519 | 5 mg | $195.00 | 19 | |
This compound disrupts actin filaments, which are crucial for the trafficking and insertion of Glut5 into the cell membrane. By destabilizing the cytoskeleton, Cytochalasin B indirectly inhibits the functional expression of Glut5 on the cell surface. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
This glucose analog is taken up by glucose transporters and phosphorylated, but cannot be further metabolized, potentially sequestering the phosphate and inhibiting further fructose phosphorylation, an indirect mechanism that can reduce Glut5 activity by depleting cellular ATP required for Glut5 function. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
An alkaloid that has been shown to reduce the expression of Glut1 in certain cell types, berberine may similarly reduce Glut5 expression and function by influencing cellular metabolism and reducing glucose and fructose uptake. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol affects the insulin signaling pathway, which indirectly might alter Glut5 trafficking and expression as part of the complex regulation of glucose and fructose transport in response to insulin. | ||||||
Fasentin | 392721-37-8 | sc-215012 sc-215012A | 5 mg 25 mg | $125.00 $440.00 | ||
Initially characterized as a Glut1 inhibitor, fasentin may affect Glut5 by its ability to interfere with the trafficking of glucose transporters to the plasma membrane, reducing transporter-mediated uptake of sugars. | ||||||