Glut5 Activators
The chemical class of Glut5 Activators encompasses compounds that, through various mechanisms, can increase the functional activity of the Glut5 protein. These activators operate through different pathways to either stimulate the translocation of Glut5 to the plasma membrane, where it becomes active in fructose transport, or enhance the expression levels of Glut5 within the cell. Chemicals such as metformin and AICAR are known to activate AMP-activated protein kinase (AMPK), which in turn has downstream effects on cellular energy balance and the regulation of glucose transporter proteins, including Glut5. This modulation can enhance the translocation and insertion of Glut5 into the cell membrane, increasing the cell's capacity to uptake fructose.
Additionally, chemicals that affect the insulin signaling pathway, either by increasing insulin sensitivity like epicatechin and alpha-lipoic acid, or by directly acting as agonists to insulin-responsive elements like rosiglitazone, can lead to increased activity or expression of Glut5. This is due to the role of insulin in upregulating glucose transporters in response to metabolic needs. Other compounds like zinc and adenosine can also indirectly contribute to the activation of Glut5 by modifying the signaling pathways or cellular conditions that govern the regulation of glucose transporter proteins. These activators do not bind directly to Glut5 but instead exert their influence through the modification of signaling cascades or transcription factors that govern the cellular localization and abundance of Glut5, thus influencing fructose uptake by the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates AMP-activated protein kinase (AMPK), which can enhance GLUT5 translocation to the plasma membrane. The activation of AMPK is known to affect glucose transporter proteins, potentially including Glut5. | ||||||
Cinnamic acid | 621-82-9 | sc-337631 | 1 g | $560.00 | ||
Cinnamic acid influences the insulin signaling pathway. Enhanced insulin signaling can upregulate glucose transporter proteins, indirectly leading to increased Glut5 activity on the cell surface for fructose uptake. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR stimulates AMPK, which indirectly can lead to the translocation of glucose transporters, including Glut5, to the cell membrane, thus increasing fructose uptake capacity. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine through its action on A2 receptors can activate adenylate cyclase, raising cAMP levels, which may lead to the activation of protein kinase A (PKA). PKA can subsequently increase Glut5 translocation to the membrane. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates transient receptor potential vanilloid 1 (TRPV1), which can stimulate glucose uptake via signaling pathways that might cross-talk with Glut5 regulatory mechanisms, enhancing its activity. | ||||||
(−)Epicatechin | 490-46-0 | sc-205672 sc-205672A | 1 mg 5 mg | $51.00 $138.00 | ||
(-)Epicatechin, a flavonoid, can enhance insulin sensitivity, potentially increasing the expression and activity of glucose transporters including Glut5, by potentiating the insulin signaling pathway. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
α-Lipoic Acid improves insulin sensitivity and might enhance Glut5 activity by modulating signaling pathways that regulate the trafficking and expression of glucose transporters. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol may upregulate peroxisome proliferator-activated receptor (PPAR) signaling, which is associated with the transcriptional regulation of various glucose transporters, potentially affecting Glut5 expression. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
As a PPAR gamma agonist, rosiglitazone can modulate transcription factors that increase the expression of glucose transporters, possibly including Glut5, thereby enhancing fructose uptake. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc can modulate insulin signaling and has been implicated in the regulation of glucose transporter expression and activity. It may play a role in the upregulation of Glut5 on the cell surface. | ||||||