GlcAT-I Activators
GlcAT-I, or Glucuronyltransferase-I, is an enzyme that plays a critical role in the biosynthesis of glycosaminoglycans (GAGs), specifically in the addition of glucuronic acid to the growing GAG chain. This enzymatic activity is essential for the formation of GAGs such as chondroitin sulfate and heparan sulfate, which are major components of the extracellular matrix found in connective tissues.
The function of GlcAT-I is pivotal in various biological processes, including cell signaling, cell adhesion, and the regulation of cell proliferation. By contributing to the structure of proteoglycans, GlcAT-I influences the physical properties of tissues, such as elasticity and compressive resistance, which are particularly important in cartilage and other load-bearing matrices.The activity of GlcAT-I is tightly regulated, as imbalances can lead to disorders in bone development and joint function, exemplified by conditions such as osteoarthritis. Moreover, because GAGs are involved in the binding of growth factors and cytokines, GlcAT-I indirectly participates in modulating the availability of these signaling molecules, thereby affecting wound healing and tissue regeneration.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression during development and could increase GlcAT-I expression as part of differentiation processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises cAMP levels, which may lead to the upregulation of GlcAT-I expression through activation of protein kinase A (PKA) signaling pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
As a glucocorticoid, dexamethasone can modulate gene expression and might upregulate GlcAT-I as part of the stress response. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in signaling pathways that can modulate gene expression, possibly including GlcAT-I. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor can cause demethylation of gene promoters, potentially leading to the activation of GlcAT-I expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can lead to chromatin remodeling and potentially increase the expression of GlcAT-I. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol can influence gene expression through estrogen receptor signaling and may affect GlcAT-I expression. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As an inducer of oxidative stress, hydrogen peroxide can activate various signaling pathways that may lead to the upregulation of GlcAT-I. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has anti-inflammatory properties and may modulate the expression of genes involved in cell cycle regulation, including GlcAT-I. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to affect gene expression and could potentially influence the expression of GlcAT-I through its action on sirtuins and other signaling pathways. | ||||||