GIOT-1 Activators
GIOT-1 Activators comprise a diverse array of chemical compounds that indirectly facilitate the functional activity of GIOT-1 through various signaling mechanisms and cellular processes. Compounds like Forskolin and Ionomycin, by increasing intracellular levels of cAMP and calcium respectively, activate PKA and calcium-dependent signaling pathways. These activations potentially enhance GIOT-1's functional role in cellular signaling and communication. Similarly, PMA, through PKC activation, and the PI3K inhibitor LY294002, can modulate substrates and pathways that intersect with GIOT-1's functional landscape, thereby amplifying its activity in related cellular processes.
Further, the influence of MEK inhibitors such as PD98059 and U0126 on the MAPK/ERK pathway, along with the p38 MAPK inhibitor SB203580, indicates a potential enhancement of GIOT-1 activity in cell proliferation and stress response. Rapamycin's impact on mTOR signaling pathways also suggests an indirect modulation of GIOT-1's role in cellular growth and metabolism.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels, potentially enhancing GIOT-1 activity by activating PKA. This can lead to the phosphorylation of substrates that interact with GIOT-1, influencing its role in cellular signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin, a calcium ionophore, increases intracellular calcium levels, potentially activating calcium-dependent signaling pathways that interact with GIOT-1, enhancing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC, which can phosphorylate substrates affecting GIOT-1 activity, potentially enhancing its role in signaling pathways and cellular processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, can indirectly affect GIOT-1 by altering the PI3K/Akt pathway, which is involved in a range of cellular functions that may interact with GIOT-1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059, a MEK inhibitor, could influence GIOT-1 activity by modulating the MAPK/ERK pathway, which plays a role in cell proliferation and survival processes where GIOT-1 might be involved. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, can influence GIOT-1 activity by affecting stress response pathways, potentially altering the cellular context in which GIOT-1 operates. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, indirectly impacts GIOT-1 by modulating cellular growth and metabolism, pathways in which GIOT-1 could be involved. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can enhance GIOT-1 activity by reducing competition from tyrosine kinase signaling, potentially influencing cellular processes involving GIOT-1. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine can modulate ion channel activity and influence intracellular signaling pathways, potentially impacting GIOT-1 activity in processes like cellular communication and response to stimuli. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin impacts various signaling pathways, including NF-κB, which can indirectly enhance GIOT-1's functional activity in processes like inflammation and cellular stress response. | ||||||