GIOT-1 Antibody (C-12): sc-398187

GIOT-1 Antibody (C-12) is a mouse monoclonal IgM antibody that detects GIOT-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GIOT-1 (C-12) antibody is available as the non-conjugated form. GIOT-1, also known as Gonadotropin-inducible transcription repressor 1 or ZNF 461, is a 563 amino acid protein that belongs to the Krüppel C2H2-type zinc-finger protein family. GIOT-1 is primarily localized in the nucleus and is widely expressed across various tissues, with the highest expression levels found in the liver, kidney, small intestine, pancreas, and thymus. GIOT-1 features 12 C2H2-type zinc fingers and one KRAB domain, which plays a crucial role in transcriptional repression by binding to specific DNA sequences. This function allows GIOT-1 to regulate gene expression in response to hormonal signals, thereby influencing various biological processes such as development and metabolism. The gene encoding GIOT-1 is located on chromosome 19q13.12, and alternative splicing results in two isoforms, further diversifying functional roles in cellular processes.

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GIOT-1 Antibody (C-12) References:

1. Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family.  |  Mizutani, T., et al. 2001. Mol Endocrinol. 15: 1693-705. PMID: 11579202
2. Involvement of cyclic adenosine 5'-monophosphate response element-binding protein, steroidogenic factor 1, and Dax-1 in the regulation of gonadotropin-inducible ovarian transcription factor 1 gene expression by follicle-stimulating hormone in ovarian granulosa cells.  |  Yazawa, T., et al. 2003. Endocrinology. 144: 1920-30. PMID: 12697699
3. KRAB-containing zinc-finger repressor proteins.  |  Urrutia, R. 2003. Genome Biol. 4: 231. PMID: 14519192
4. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-->q13.4.  |  Dai, J., et al. 2003. Cytogenet Genome Res. 103: 74-8. PMID: 15004467
5. Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2.  |  Song, KH., et al. 2006. J Biol Chem. 281: 15605-14. PMID: 16595694
6. [Progress in the study of KRAB zinc finger protein].  |  Tian, CY., et al. 2006. Yi Chuan. 28: 1451-6. PMID: 17098717
7. Transcription factor expression in the hypothalamo-neurohypophyseal system of the dehydrated rat: upregulation of gonadotrophin inducible transcription factor 1 mRNA is mediated by cAMP-dependent protein kinase A.  |  Qiu, J., et al. 2007. J Neurosci. 27: 2196-203. PMID: 17329416
8. Sequencing human-gibbon breakpoints of synteny reveals mosaic new insertions at rearrangement sites.  |  Girirajan, S., et al. 2009. Genome Res. 19: 178-90. PMID: 19029537

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GIOT-1 Antibody (C-12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GIOT-1 Antibody (C-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GIOT-1 Antibody (C-12) Specifications

Alternate Product Name: GIOT-1

Product Clone Name: C-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 71-98

Epitope Target: GIOT-1

Epitope Species: human

Product Reactivity/Detection: GIOT-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GIOT-1 Antibody (C-12): P: Blocking Peptide