Date published: 2026-5-5

1-800-457-3801

SCBT Portrait Logo
Seach Input

General Crosslinkers

Santa Cruz Biotechnology now offers a broad range of crosslinkers for use in various applications. Crosslinkers are versatile chemical agents that can form covalent bonds between different molecules, thus linking them together. These compounds are crucial in scientific research for stabilizing the structure of proteins, nucleic acids, and other biomolecules, allowing for more accurate studies of their functions and interactions. By creating crosslinked networks, researchers can investigate the three-dimensional structure of macromolecules, study the dynamics of complex biological systems, and enhance the durability and functionality of biomaterials. In material science, crosslinkers are used to develop polymers with improved mechanical properties, such as increased strength and resistance to solvents and heat. Additionally, they play a vital role in developing and optimizing new materials, adhesives, coatings, and composites. The ability of crosslinkers to create strong, stable bonds has also been utilized in various biochemical techniques, such as immunoprecipitation, chromatography, and mass spectrometry, where they help in isolating and identifying specific molecules from complex mixtures. Santa Cruz Biotechnology provides a wide selection of crosslinkers, each with unique properties tailored for specific research needs, ensuring researchers have the tools necessary for their studies. View detailed information on our available crosslinkers by clicking on the product name.

Items 271 to 280 of 343 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

3-(Maleimidopropane-1-carbonyl-1-(tert-butyl)carbazate

1076198-38-3sc-357585
100 mg
$330.00
(0)

3-(Maleimidopropane-1-carbonyl-1-(tert-butyl)carbazate is a versatile crosslinker characterized by its maleimide functionality, which engages in selective thiol reactions to form robust covalent bonds. The presence of a tert-butyl group enhances steric hindrance, influencing reaction kinetics and stability. This compound's unique structure allows for tailored crosslinking in diverse environments, promoting the formation of intricate networks and enabling precise control over material properties and interactions.

11-Maleimidoundecane-1-carbonyl-1-(t-butyl)carbazate

1076198-39-4sc-213587
25 mg
$300.00
(0)

11-Maleimidoundecane-1-carbonyl-1-(t-butyl)carbazate serves as a versatile crosslinker, characterized by its maleimide functionality that enables selective thiol conjugation. This compound exhibits unique reactivity with sulfhydryl groups, facilitating the formation of stable thioether bonds. Its long aliphatic chain enhances solubility and flexibility, promoting effective network formation in polymer matrices. The t-butyl group contributes to steric hindrance, influencing reaction kinetics and selectivity in crosslinking processes.

[N-(2-Maleimidoethyl]ethylenediamine-N,N,N′,N′-tetraacetic Acid, Monoamide

1185102-85-5sc-218919
10 mg
$360.00
(0)

N-(2-Maleimidoethyl)ethylenediamine-N,N,N',N'-tetraacetic Acid, Monoamide acts as a versatile crosslinker, characterized by its maleimide functionality that enables selective thiol reactions. This compound exhibits a high degree of specificity in crosslinking, allowing for tailored network formation. Its unique chelating ability enhances interaction with various substrates, promoting efficient polymerization and improving the overall durability and resilience of the resultant materials.

Propargyl-succinimidyl-ester

1174157-65-3sc-397263
sc-397263A
sc-397263B
50 mg
250 mg
1 g
$102.00
$326.00
$660.00
(0)

Propargyl-succinimidyl-ester acts as a versatile crosslinker, characterized by its unique ability to engage in click chemistry through the formation of stable covalent bonds with nucleophiles. The presence of the propargyl group enables efficient alkyne-azide cycloaddition reactions, promoting rapid crosslinking. Its reactive succinimidyl ester moiety enhances the kinetics of amine coupling, facilitating precise control over polymer network architecture and functionalization.

DBCO-maleimide

sc-397264
sc-397264A
1 mg
5 mg
$17.00
$81.00
(0)

DBCO-maleimide serves as a versatile crosslinker, characterized by its unique ability to engage in strain-promoted azide-alkyne cycloaddition. This reaction pathway allows for rapid and selective covalent bond formation, facilitating the creation of complex networks. Its distinct reactivity with thiol groups enhances the stability of crosslinked structures, while the inherent rigidity of the maleimide moiety contributes to the mechanical strength of the resulting materials.

DBCO-PEG4-maleimide

1480516-75-3sc-397265
sc-397265A
sc-397265B
1 mg
5 mg
50 mg
$47.00
$119.00
$355.00
(0)

DBCO-PEG4-maleimide is a specialized crosslinker known for its efficient thiol-maleimide click chemistry, enabling precise and stable covalent bonding. The PEG4 spacer enhances solubility and flexibility, promoting better accessibility to reactive sites. This compound exhibits rapid reaction kinetics, allowing for swift network formation. Its unique structure facilitates the creation of well-defined polymer architectures, contributing to improved mechanical properties and functional versatility in various applications.

Dibenzocyclooctyne-N-hydroxysuccinimidyl ester

1353016-71-3sc-397268
sc-397268A
1 mg
5 mg
$27.00
$81.00
(0)

Dibenzocyclooctyne-N-hydroxysuccinimidyl ester is a versatile crosslinker that utilizes strain-promoted azide-alkyne cycloaddition for efficient covalent bonding. Its unique dibenzocyclooctyne moiety enhances reactivity with azides, enabling rapid and selective crosslinking. The N-hydroxysuccinimidyl ester group facilitates amine coupling, promoting diverse functionalization. This compound's robust reaction kinetics and stability under physiological conditions make it ideal for creating complex biomolecular networks.

Acetylene-PEG5-NHS ester

1393330-40-9sc-397269
sc-397269A
10 mg
25 mg
$77.00
$163.00
(0)

Acetylene-PEG5-NHS ester functions as a versatile crosslinker, leveraging its NHS ester group to react efficiently with amines, forming stable amide bonds. The presence of the PEG spacer enhances solubility and biocompatibility, promoting uniform distribution in various environments. Its unique reactivity allows for rapid conjugation under mild conditions, facilitating the formation of complex networks. This compound's ability to create diverse linkages makes it a powerful tool in polymer chemistry and materials development.

Alkyne-PEG4-maleimide

sc-397271
sc-397271A
10 mg
25 mg
$55.00
$127.00
(0)

Alkyne-PEG4-maleimide is a versatile crosslinker featuring a maleimide group that selectively reacts with thiols, enabling the formation of stable thioether bonds. The PEG4 spacer enhances solubility and flexibility, promoting efficient crosslinking in diverse environments. Its alkyne functionality allows for click chemistry applications, facilitating rapid and specific conjugation reactions. This compound's unique reactivity and tunable properties make it ideal for constructing complex polymer architectures.

monodisperse Mal-PEG4-NHS-ester

756525-99-2sc-397273
100 mg
$323.00
(0)

Monodisperse Mal-PEG4-NHS-ester is a specialized crosslinker characterized by its NHS ester functionality, which readily reacts with amines to form stable amide bonds. The monodisperse nature ensures uniformity in molecular weight, leading to consistent reaction kinetics. The PEG4 spacer enhances solubility and biocompatibility, while its unique reactivity allows for precise control over crosslinking density, facilitating the design of tailored polymer networks with predictable properties.