Date published: 2026-4-24

1-800-457-3801

SCBT Portrait Logo
Seach Input

Propargyl-succinimidyl-ester (CAS 1174157-65-3)

0.0(0)
Write a reviewAsk a question

Alternate Names:
Propargyl-N-hydroxysuccinimidyl ester
Application:
Propargyl-succinimidyl-ester is an amine reactive crosslinker for incorporation of a terminal alkyne
CAS Number:
1174157-65-3
Molecular Weight:
225.20
Molecular Formula:
C10H11NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Propargyl-succinimidyl-ester is a chemical reagent used in bioconjugation chemistry, which enables the attachment of various molecules to proteins or other biomolecules. Its alkyne group is particularly reactive towards azides in a click chemistry context, a type of reaction that is highly valued for its specificity and efficiency under mild conditions. Researchers employ this compound to label proteins with fluorescent dyes or other probes for subsequent visualization and detection in a variety of biological assays. Its utility in studying protein interactions, localization, and turnover is useful in cell biology and proteomics. Moreover, propargyl-succinimidyl-ester aids in the development of new diagnostic tools, where it is used to create sophisticated detection reagents that can specifically latch onto biomarkers of interest. Its role in the synthesis of complex molecules via click chemistry also extends to materials science, where it is used to functionalize surfaces or create novel polymer structures.


Propargyl-succinimidyl-ester (CAS 1174157-65-3) References

  1. NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots.  |  Ward, CC., et al. 2017. ACS Chem Biol. 12: 1478-1483. PMID: 28445029
  2. Inhibitor-GCPII Interaction: Selective and Robust System for Targeting Cancer Cells with Structurally Diverse Nanoparticles.  |  Neburkova, J., et al. 2018. Mol Pharm. 15: 2932-2945. PMID: 29389139
  3. Placement of Single Proteins within the SERS Hot Spots of Self-Assembled Silver Nanolenses.  |  Heck, C., et al. 2018. Angew Chem Int Ed Engl. 57: 7444-7447. PMID: 29575472
  4. Nanoparticle-cell interactions induced apoptosis: a case study with nanoconjugated epidermal growth factor.  |  Khanehzar, A., et al. 2018. Nanoscale. 10: 6712-6723. PMID: 29589623
  5. Surface Immobilization of Viruses and Nanoparticles Elucidates Early Events in Clathrin-Mediated Endocytosis.  |  Fratini, M., et al. 2018. ACS Infect Dis. 4: 1585-1600. PMID: 30200751
  6. Ligand Density and Nanoparticle Clustering Cooperate in the Multivalent Amplification of Epidermal Growth Factor Receptor Activation.  |  Zhang, Q. and Reinhard, BM. 2018. ACS Nano. 12: 10473-10485. PMID: 30289688
  7. Soluble Antigen Arrays for Selective Desensitization of Insulin-Reactive B Cells.  |  Leon, MA., et al. 2019. Mol Pharm. 16: 1563-1572. PMID: 30681867
  8. New lectin ligands: Testing of Amadori rearrangement products with a series of mannoside-specific lectins.  |  Prasch, H., et al. 2019. Carbohydr Res. 475: 65-68. PMID: 30844665
  9. Functionalizing Cellulose Nanocrystals with Click Modifiable Carbohydrate-Binding Modules.  |  Aïssa, K., et al. 2019. Biomacromolecules. 20: 3087-3093. PMID: 31260278
  10. Activated Plasmonic Nanoaggregates for Dark-Field in Situ Imaging for HER2 Protein Imaging on Cell Surfaces.  |  Guo, Y., et al. 2020. Bioconjug Chem. 31: 631-638. PMID: 31944094
  11. Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage.  |  Sojitra, M., et al. 2021. Nat Chem Biol. 17: 806-816. PMID: 33958792
  12. Synthesis and Preclinical Evaluation of [18F]SiFA-PSMA Inhibitors in a Prostate Cancer Model.  |  Bailey, JJ., et al. 2021. J Med Chem. 64: 15671-15689. PMID: 34672630
  13. Multivalent Ligand-Nanoparticle Conjugates Amplify Reactive Oxygen Species Second Messenger Generation and Enhance Epidermal Growth Factor Receptor Phosphorylation.  |  Zhang, S., et al. 2022. Bioconjug Chem. 33: 1716-1728. PMID: 35993676

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Propargyl-succinimidyl-ester, 50 mg

sc-397263
50 mg
$102.00

Propargyl-succinimidyl-ester, 250 mg

sc-397263A
250 mg
$326.00

Propargyl-succinimidyl-ester, 1 g

sc-397263B
1 g
$660.00