Molecular structure of DBCO-PEG4-maleimide, CAS Number: 1480516-75-3
DBCO-PEG4-maleimide (CAS 1480516-75-3)
Alternate Names:
Dibenzocyclooctyne-PEG4-maleimide; DBCO-PEG4-maleimide
Application:
DBCO-PEG4-maleimide is a sulfhydryl reactive crosslinker for incorporation of the cyclooctyne moiety
CAS Number:
1480516-75-3
Molecular Weight:
674.74
Molecular Formula:
C36H42N4O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
DBCO-PEG4-maleimide is a maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG lipophilic spacer helps to reduce aggregation and precipitation problems when labeling biomolecules.
DBCO-PEG,[object Object],-maleimide (CAS 1480516-75-3) References
- Nano-scale alignment of proteins on a flexible DNA backbone. | Nojima, T., et al. 2012. PLoS One. 7: e52534. PMID: 23300700
- Engineering induction of singular neural rosette emergence within hPSC-derived tissues. | Knight, GT., et al. 2018. Elife. 7: PMID: 30371350
- Cysteine-Directed Bioconjugation of a Platinum(II)-Acridine Anticancer Agent. | Yao, X., et al. 2019. Inorg Chem. 58: 43-46. PMID: 30543413
- Synthesis and Fabrication of Surface-Active Microparticles Using a Membrane Emulsion Technique and Conjugation of Model Protein via Strain-Promoted Azide-Alkyne Click Chemistry in Physiological Conditions. | Walden, G., et al. 2019. Bioconjug Chem. 30: 531-535. PMID: 30730698
- Visualization of a novel human monoclonal antibody against Claudin-3 for targeting ovarian cancer. | Oh, S., et al. 2022. Nucl Med Biol. 114-115: 135-142. PMID: 35501237
- A Potent Micron Neoantigen Tumor Vaccine GP-Neoantigen Induces Robust Antitumor Activity in Multiple Tumor Models. | Jing, Z., et al. 2022. Adv Sci (Weinh). 9: e2201496. PMID: 35712770
- Development of Radiotracers for Imaging of the PD-1/PD-L1 Axis. | Krutzek, F., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 35745666
- The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead. | Nguyen, KA., et al. 2022. Eur J Med Chem. 244: 114863. PMID: 36334452
- miRNA circuit modules for precise, tunable control of gene expression. | Du, R., et al. 2024. bioRxiv.. PMID: 38559239
- Engineering the Mechanical Stability of a Therapeutic Affibody/PD-L1 Complex by Anchor Point Selection. | Yang, B., et al. 2024. bioRxiv.. PMID: 38826272
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DBCO-PEG4-maleimide, 1 mg | sc-397265 | 1 mg | $47.00 | |||
DBCO-PEG4-maleimide, 5 mg | sc-397265A | 5 mg | $119.00 | |||
DBCO-PEG4-maleimide, 50 mg | sc-397265B | 50 mg | $355.00 |