Date published: 2026-5-5

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General Crosslinkers

Santa Cruz Biotechnology now offers a broad range of crosslinkers for use in various applications. Crosslinkers are versatile chemical agents that can form covalent bonds between different molecules, thus linking them together. These compounds are crucial in scientific research for stabilizing the structure of proteins, nucleic acids, and other biomolecules, allowing for more accurate studies of their functions and interactions. By creating crosslinked networks, researchers can investigate the three-dimensional structure of macromolecules, study the dynamics of complex biological systems, and enhance the durability and functionality of biomaterials. In material science, crosslinkers are used to develop polymers with improved mechanical properties, such as increased strength and resistance to solvents and heat. Additionally, they play a vital role in developing and optimizing new materials, adhesives, coatings, and composites. The ability of crosslinkers to create strong, stable bonds has also been utilized in various biochemical techniques, such as immunoprecipitation, chromatography, and mass spectrometry, where they help in isolating and identifying specific molecules from complex mixtures. Santa Cruz Biotechnology provides a wide selection of crosslinkers, each with unique properties tailored for specific research needs, ensuring researchers have the tools necessary for their studies. View detailed information on our available crosslinkers by clicking on the product name.

Items 281 to 290 of 343 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Maleimide-PEG2-NHS

955094-26-5sc-397274
sc-397274A
50 mg
250 mg
$178.00
$510.00
(0)

Maleimide-PEG2-NHS is a versatile crosslinker featuring a maleimide group that selectively reacts with thiol-containing compounds, forming stable thioether bonds. The PEG2 spacer enhances solubility and flexibility, promoting efficient molecular interactions. Its unique reactivity allows for rapid and specific crosslinking, enabling the formation of complex networks with controlled architecture. This specificity and tunability make it ideal for crafting diverse polymeric structures with tailored mechanical properties.

Maleimide-PEG12-NHS ester

1426151-00-9sc-397277
sc-397277A
50 mg
250 mg
$347.00
$765.00
(0)

Maleimide-PEG12-NHS ester is a specialized crosslinker characterized by its maleimide moiety, which exhibits a strong affinity for thiol groups, facilitating the formation of robust thioether linkages. The extended PEG12 chain enhances hydrophilicity and steric hindrance, allowing for improved solvation and reduced aggregation. This compound's rapid reaction kinetics enable efficient crosslinking, while its unique structural features support the creation of intricate polymer networks with customizable properties and functionalities.

Maleimide-PEG8-NHS ester

756525-93-6sc-397276
sc-397276A
50 mg
250 mg
$206.00
$599.00
(0)

Maleimide-PEG8-NHS ester is a versatile crosslinker characterized by its ability to form stable covalent bonds with thiol groups, facilitating the creation of complex biomolecular networks. The PEG spacer enhances solubility and biocompatibility, while the NHS ester group promotes efficient reaction kinetics with amines. This compound's unique structure allows for precise control over crosslinking density, enabling tailored modifications in various applications, including material science and bioconjugation.

SDA (NHS-Diazirine)

sc-397278
50 mg
$437.00
(1)

SDA (NHS-Diazirine) is a versatile crosslinker known for its unique diazirine moiety, which enables rapid and selective covalent bonding under mild conditions. Its reactivity is characterized by the formation of stable, covalent linkages with nucleophiles, driven by the strain in the diazirine ring. This compound exhibits remarkable stability in various environments, allowing for efficient incorporation into complex biomolecular structures, thus facilitating innovative approaches in material science and bioconjugation.

SDAD (NHS-SS-Diazirine)

sc-397280
25 mg
$605.00
(0)

SDAD (NHS-SS-Diazirine) is a distinctive crosslinker featuring a diazirine group that undergoes photochemical activation, enabling targeted covalent modifications. Its unique reactivity profile allows for the formation of robust linkages with thiols and amines, promoting specific interactions in diverse chemical environments. The compound's ability to engage in rapid reaction kinetics enhances its utility in creating intricate networks, making it a valuable tool for advancing polymer chemistry and materials development.

Sulfo-SDA (Sulfo-NHS-Diazirine)

sc-397281
50 mg
$650.00
(0)

Sulfo-SDA (Sulfo-NHS-Diazirine) is a specialized crosslinker characterized by its sulfonate group, which enhances solubility and reactivity in aqueous environments. This compound features a diazirine moiety that, upon UV irradiation, generates reactive carbene species, facilitating covalent bonding with nucleophiles such as amines and thiols. Its unique mechanism allows for precise spatial control in crosslinking, enabling the formation of complex, three-dimensional structures with tailored properties.

Sulfo-LC-SDA (Sulfo-NHS-LC-Diazirine)

sc-397283
50 mg
$552.00
(0)

Sulfo-LC-SDA (Sulfo-NHS-LC-Diazirine) is a versatile crosslinker distinguished by its long, flexible linker that enhances steric accessibility and reaction efficiency. The sulfonate group improves solubility in biological systems, while the diazirine component, upon exposure to light, produces highly reactive carbenes. This enables rapid and selective covalent attachment to various biomolecules, allowing for intricate network formations and dynamic interactions in complex environments.

Sulfo-SDAD (Sulfo-NHS-SS-Diazirine)

sc-397284
50 mg
$764.00
(0)

Sulfo-SDAD (Sulfo-NHS-SS-Diazirine) is a specialized crosslinker characterized by its unique disulfide bond, which provides reversible linkage under reducing conditions. The sulfonate moiety enhances aqueous solubility, facilitating interactions in diverse environments. Its diazirine structure generates reactive carbenes upon UV activation, enabling precise covalent modifications. This property allows for the formation of stable yet dynamic crosslinked networks, promoting intricate molecular interactions and tailored assembly in various applications.

L-Photo-Leucine

sc-397286
100 mg
$700.00
(0)

L-Photo-Leucine serves as a versatile crosslinker, distinguished by its ability to form stable covalent bonds through unique side-chain interactions. Its photo-reactive properties enable selective activation under light exposure, facilitating controlled crosslinking in complex systems. The presence of specific functional groups enhances its reactivity, allowing for rapid kinetics in forming robust networks. This adaptability supports diverse molecular architectures, promoting innovative approaches in material science and bioconjugation.

L-Photo-Methionine

sc-397287
100 mg
$1020.00
(0)

L-Photo-Methionine acts as an effective crosslinker, characterized by its sulfur-containing side chain that facilitates unique thiol-based interactions. Its photoreactive nature allows for targeted activation, enabling precise control over crosslinking dynamics. The compound exhibits distinct reaction kinetics, promoting rapid formation of crosslinked networks under specific light conditions. This property enhances its compatibility with various substrates, paving the way for innovative structural designs in polymer chemistry and materials engineering.