Molecular structure of Sulfo-SDAD (Sulfo-NHS-SS-Diazirine)
Sulfo-SDAD (Sulfo-NHS-SS-Diazirine)
Alternate Names:
Sulfosuccinimidyl 2-([4,4′-azipentanamido]ethyl)-1,3′-dithiopropionate
Application:
Sulfo-SDAD (Sulfo-NHS-SS-Diazirine) is a sulfo-NHS-diazirine based photoreactive crosslinker. Membrane impermeable and cleavable with a 13.5 Angstrom spacer arm.
Molecular Weight:
490.51
Molecular Formula:
C14H19N4NaO8S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sulfo-SDAD (Sulfo-NHS-SS-Diazirine) is an amine and photoreactive, membrane impermeable, cleavable heterobifunctional crosslinker with a 13.5 Angstrom spacer arm. The diazirine photoreactive group has improved photostability over aryl azides, yet is more efficiently activated by long-wave UV light (330-370nm). Activation of the diazirine releases nitrogen to produce a highly reactive carbene intermediate, which then indiscriminately bonds with nearby functional group.
Sulfo-SDAD (Sulfo-NHS-SS-Diazirine) References
- Mesenchymal stem cells inhibit both endogenous and exogenous MMPs via secreted TIMPs. | Lozito, TP. and Tuan, RS. 2011. J Cell Physiol. 226: 385-96. PMID: 20665704
- Integrin αPS3/βν-mediated phagocytosis of apoptotic cells and bacteria in Drosophila. | Nonaka, S., et al. 2013. J Biol Chem. 288: 10374-80. PMID: 23426364
- Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. | Maejima, Y., et al. 2013. Nat Med. 19: 1478-88. PMID: 24141421
- Interaction of enzymes of the tricarboxylic acid cycle in Bacillus subtilis and Escherichia coli: a comparative study. | Jung, T. and Mack, M. 2018. FEMS Microbiol Lett. 365: PMID: 29546354
- O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis. | Li, X., et al. 2019. Proc Natl Acad Sci U S A. 116: 7857-7866. PMID: 30940748
- A role of heparan sulphate proteoglycan in the cellular uptake of lipocalins ß-lactoglobulin and allergen Fel d 4. | Habeler, M., et al. 2020. Biol Chem. 401: 1081-1092. PMID: 32229688
- Photo selective protein immobilization using bovine serum albumin. | Kim, Wan-Joong, et al. 2012. Applied surface science. 261: 880-889.
- Abstract P5-08-03: Poly-ligand profiling and target identification from formalin-fixed-paraffin embedded HER2+ breast cancer specimens. | O'Neill, H. A., et al. 2018. Cancer Research. 78.4_Supplement: P5-08.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulfo-SDAD (Sulfo-NHS-SS-Diazirine), 50 mg | sc-397284 | 50 mg | $764.00 |