γ-catenin Inhibitors
γ-catenin inhibitors are a class of chemical compounds that target a specific protein called γ-catenin, which plays a crucial role in various cellular processes, particularly those related to cell adhesion and signaling pathways. γ-catenin is a member of the catenin family of proteins, which are primarily known for their involvement in the Wnt signaling pathway and their association with cadherins, the cell-cell adhesion molecules. Within the context of cell adhesion, γ-catenin serves as a key mediator, bridging the connection between cadherins and the actin cytoskeleton. This interaction is essential for maintaining the integrity of tissues and ensuring proper cell adhesion, which is fundamental in processes such as tissue development, homeostasis, and wound healing.
Inhibitors targeting γ-catenin are designed to interfere with its activity or expression, disrupting the normal functioning of cellular processes in which γ-catenin is involved. By modulating γ-catenin, these inhibitors influence cell adhesion, cell motility, and various signaling pathways, which can have significant implications in the context of disease research and drug development. Understanding the molecular mechanisms underlying γ-catenin inhibitors' effects is crucial for elucidating their roles in various biological contexts, including cancer, tissue regeneration, and developmental biology. Research into γ-catenin inhibitors continues to shed light on their precise mechanisms of action and their applications in manipulating cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil is a pyrimidine analog that interferes with DNA synthesis. It may reduce γ-catenin expression by disrupting cellular proliferation and inducing apoptosis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, has anti-inflammatory properties. It may modulate γ-catenin expression indirectly through its effects on various signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane is found in cruciferous vegetables and has demonstrated anti-cancer properties. It may affect γ-catenin expression by modulating antioxidant response elements. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes. It has been shown to modulate various signaling pathways, potentially leading to reduced γ-catenin expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties. It may influence γ-catenin expression through its effects on cellular oxidative stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a major component of green tea. It may modulate γ-catenin expression through its effects on cellular proliferation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a macrolide compound that inhibits mTOR, a key regulator of cell growth. It may decrease γ-catenin expression by reducing cellular proliferation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of PI3K, a kinase involved in various cellular processes. It may modulate γ-catenin expression by affecting downstream signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a specific inhibitor of MEK, a kinase involved in the MAPK signaling pathway. It may alter γ-catenin expression by modulating cellular signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, a protein kinase involved in stress responses. It may influence γ-catenin expression by modulating cellular stress pathways. | ||||||