γ-catenin Antibody (A-6): sc-514115

γ-catenin Antibody (A-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects gamma-catenin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-gamma-catenin antibody (A-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. gamma-catenin protein, also known as plakoglobin, plays a crucial role in cellular adhesion by forming complexes with cadherins, particularly E-cadherin and N-cadherin. These complexes are essential for maintaining epithelial tissue integrity and facilitating intercellular communication. gamma-catenin in these complexes not only stabilizes cadherin-catenin interactions but also participates in signaling pathways that regulate cell proliferation and differentiation. Alterations in gamma-catenin expression or function have been implicated in various diseases, including cancer, where disrupted cell adhesion can lead to increased invasiveness and metastasis. gamma-catenin (A-6) antibody serves as a valuable tool for researchers investigating cell adhesion mechanisms and cadherin-catenin complexes in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

γ-catenin Antibody (A-6) References:

1. gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth.  |  Winn, RA., et al. 2002. Oncogene. 21: 7497-506. PMID: 12386812
2. Identification of the regions of PECAM-1 involved in beta- and gamma-catenin associations.  |  Biswas, P., et al. 2005. Biochem Biophys Res Commun. 329: 1225-33. PMID: 15766557
3. Downregulation of γ-catenin inhibits CML cell growth and potentiates the response of CML cells to imatinib through β-catenin inhibition.  |  Niu, CC., et al. 2013. Int J Mol Med. 31: 453-8. PMID: 23233089
4. Mice with Hepatic Loss of the Desmosomal Protein γ-Catenin Are Prone to Cholestatic Injury and Chemical Carcinogenesis.  |  Zhou, L., et al. 2015. Am J Pathol. 185: 3274-89. PMID: 26485505
5. THBS1/CD47 Modulates the Interaction of γ-Catenin With E-Cadherin and Participates in Epithelial-Mesenchymal Transformation in Lipid Nephrotoxicity.  |  Gao, L., et al. 2020. Front Cell Dev Biol. 8: 601521. PMID: 33681182
6. Frequent alterations in E-cadherin and alpha- and beta-catenin expression in human breast cancer cell lines.  |  Pierceall, WE., et al. 1995. Oncogene. 11: 1319-26. PMID: 7478552
7. Role of the E-cadherin/alpha-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells.  |  Breen, E., et al. 1995. Ann Surg Oncol. 2: 378-85. PMID: 7496831
8. Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo.  |  Brady-Kalnay, SM., et al. 1995. J Cell Biol. 130: 977-86. PMID: 7642713
9. Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.  |  Sacco, PA., et al. 1995. J Biol Chem. 270: 20201-6. PMID: 7650039
10. Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin.  |  Knudsen, KA., et al. 1995. J Cell Biol. 130: 67-77. PMID: 7790378
11. Beta-catenin expression in human cancers.  |  Takayama, T., et al. 1996. Am J Pathol. 148: 39-46. PMID: 8546224
12. Cloning of an alternative form of plakoglobin (gamma-catenin) lacking the fourth armadillo repeat.  |  Ozawa, M., et al. 1995. J Biochem. 118: 836-40. PMID: 8576101

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-γ-catenin Antibody (A-6) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-γ-catenin Antibody (A-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

γ-catenin Antibody (A-6) Specifications

Alternate Product Name: Catenin Gamma

Product Clone Name: A-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 689-713

Epitope Target: γ-catenin

Epitope Species: human

Product Reactivity/Detection: γ-catenin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for γ-catenin Antibody (A-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin