GAGE5 Activators
Activators of GAGE5 are postulated to work through several biochemical mechanisms to exert their influence on the protein's function. Chemicals that elevate intracellular levels of secondary messengers, such as cAMP, may enhance the activity of protein kinases that could phosphorylate and activate GAGE5. Additionally, agents that modulate the intracellular calcium concentration could trigger calcium-dependent signaling pathways, which may have downstream effects on the function of GAGE5. Histone deacetylase inhibitors, by altering chromatin structure, could increase the accessibility of transcription factors to the GAGE5 gene, potentially leading to its upregulation. Similarly, DNA methyltransferase inhibitors may demethylate the gene's loci, resulting in increased GAGE5 expression.
Furthermore, compounds that interact with specific receptors or signaling pathways may also have an indirect impact on the activity of GAGE5. For instance, by binding to retinoic acid receptors, certain molecules can modulate gene expression, which might affect GAGE5. Inhibitors of specific kinases, such as PI3K, can influence downstream signaling pathways that control the expression or activation of GAGE5. Additionally, agents that activate transcriptional pathways, like the Nrf2 pathway, may modulate the expression of a wide array of genes, potentially including GAGE5. Others may engage with stress response pathways, leading to altered gene expression and potentially influencing the activity of GAGE5.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By elevating intracellular cAMP levels, Forskolin may enhance the activity of cAMP-dependent protein kinases, which could indirectly activate GAGE5 by phosphorylation processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
This diester of phorbol acts as a potent activator of protein kinase C (PKC), which may phosphorylate substrates that modulate the activity of GAGE5. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As a histone deacetylase inhibitor, Sodium butyrate could alter chromatin structure and potentially increase the accessibility of transcription factors to the GAGE5 loci, indirectly enhancing GAGE5 expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that raises intracellular calcium levels, potentially affecting calcium-dependent signaling pathways that modulate GAGE5 function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol found in green tea, EGCG may influence epigenetic modifications and thus indirectly affect the expression of cancer/testis antigens like GAGE5. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
By binding to retinoic acid receptors, it can modulate gene expression and might affect the expression or activity of GAGE5. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that could demethylate DNA and potentially lead to the upregulation of normally silenced genes including GAGE5. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that may increase the expression of genes by altering chromatin structure, potentially affecting GAGE5 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can modulate downstream AKT signaling, possibly influencing pathways that control the expression or activation of GAGE5. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
By influencing the Nrf2 pathway, Sulforaphane may indirectly affect the expression of a wide array of genes, including potentially GAGE5. | ||||||