GAGE Inhibitors
Chemical inhibitors of GAGE can exert their influence through various mechanisms that affect the chromatin structure and gene expression patterns within cells. Sulforaphane and Trichostatin A, along with Vorinostat, Romidepsin, Belinostat, Panobinostat, SAHA, Entinostat, Valproic Acid, Mocetinostat, and Chidamide, are all agents that inhibit the activity of histone deacetylases (HDACs). By doing so, these compounds can induce hyperacetylation of histones, leading to a more relaxed and open chromatin state. This alteration in chromatin structure can facilitate or hinder the access of transcriptional machinery to DNA, resulting in changes to the expression of various genes, including those that regulate the presence and function of GAGE.
Disulfiram, another chemical mentioned, operates through a different mechanism by inhibiting aldehyde dehydrogenase (ALDH), which plays a role in cellular pathways that intersect with those involving GAGE. The inhibition of ALDH by disulfiram can lead to an accumulation of aldehydes and a disruption of retinoic acid balance, which is crucial for various cellular differentiation processes. Since GAGE is implicated in certain cellular pathways, the altered aldehyde and retinoic acid levels can affect the functional activity of this protein. Overall, the actions of these chemical inhibitors can lead to a decrease in the functional activity of GAGE by modifying the cellular environment and influencing the pathways that govern its role within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane inhibits the activity of histone deacetylase, which can lead to alterations in the expression pattern of genes, including those related to the GAGE protein. By inhibiting this enzyme, sulforaphane can alter the chromatin structure and potentially reduce the functional activity of the GAGE protein through changes in gene expression that reduce its functional presence. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram inhibits aldehyde dehydrogenase (ALDH), an enzyme that may be involved in the same cellular pathways as GAGE. By inhibiting ALDH, disulfiram can alter the cellular environment in a way that could decrease the functional activity of GAGE by affecting the balance of aldehydes and retinoic acid, which are involved in various cellular differentiation pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which can cause hyperacetylation of histones, leading to an open chromatin structure and potentially affecting gene expression patterns. This change in the chromatin landscape can decrease the functional activity of GAGE by altering the transcriptional environment of cells. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat functions similarly to trichostatin A as a histone deacetylase inhibitor, potentially reducing the functional activity of GAGE by changing the chromatin structure and influencing gene expression patterns that are essential for the protein's function. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is another histone deacetylase inhibitor that can lead to changes in chromatin structure and gene expression. These changes can decrease the functional activity of GAGE by altering the transcriptional environment. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat, a histone deacetylase inhibitor, can alter chromatin dynamics and gene expression profiles, potentially leading to a decrease in the functional activity of GAGE by affecting the cellular pathways in which the protein is involved. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is a potent histone deacetylase inhibitor that can affect chromatin structure and gene expression, potentially reducing the functional activity of GAGE through alterations in cellular pathways. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat is a selective histone deacetylase inhibitor that may reduce the functional activity of GAGE by affecting gene expression and chromatin structure, thus influencing the cellular pathways in which GAGE operates. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid is a histone deacetylase inhibitor that can change the expression of genes and the structure of chromatin, potentially leading to a decrease in the functional activity of GAGE by altering its cellular context and pathways. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat is a histone deacetylase inhibitor that could cause changes in gene expression and chromatin structure, potentially diminishing the functional activity of GAGE by affecting the protein's cellular environment. | ||||||