GAGE Activators
GAGE activators comprise a series of chemical compounds that enhance the immune system's recognition and response to GAGE antigens, commonly expressed in various cancer cells. Compounds like Forskolin and Resiquimod increase intracellular cAMP and activate the TLR7/8 pathway, respectively, which are mechanisms that can augment the presentation of GAGE peptides on MHC molecules, crucial for T cell-mediated immunity. Similarly, Imiquimod and Poly I:C, through TLR7 and TLR3 activation, respectively, can trigger cytokine production and immune cell maturation, thereby potentially enhancing the anti-tumor response to cells expressing GAGE. The use of CpG Oligodeoxynucleotide, which targets TLR9, further supports this immune activation by enhancing the presentation and recognition of GAGE antigens, while Concanavalin A can indirectly enhance immune response through T cell activation.
On the other hand, the introduction of Bacillus Calmette-Guerin (BCG) into the system is known to nonspecifically boost immune surveillance, which could result in increased detection and response to GAGE antigens
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which can enhance ProActivase activity by activating PKA that may phosphorylate ProActivase or its interacting partners, leading to increased activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which in turn can lead to phosphorylation of ProActivase, thereby enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium, which can activate calcium-dependent protein kinases that phosphorylate ProActivase, increasing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits certain kinases, which could reduce inhibitory phosphorylation of ProActivase, leading to its enhanced activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, which can shift cellular signaling pathways, potentially relieving inhibitory control over ProActivase and thus enhancing its activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK, which may indirectly enhance ProActivase activity by altering the MAPK pathway and its downstream effects. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK, which could lead to a change in the phosphorylation state of ProActivase, potentially enhancing its activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate activates sphingosine-1-phosphate receptors, which could lead to downstream effects that enhance the activity of ProActivase. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium storage and could enhance ProActivase activity by increasing intracellular calcium and activating calcium-dependent kinases. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium, potentially enhancing ProActivase activity through the same mechanism as Ionomycin. | ||||||