GADD 153 Inhibitors
Common GADD 153 Inhibitors include, but are not limited to 4-Phenylbutyric acid CAS 1821-12-1, Tauroursodeoxycholic Acid, Sodium Salt CAS 14605-22-2, Salubrinal CAS 405060-95-9, Guanabenz acetate CAS 23256-50-0 and Resveratrol CAS 501-36-0.
Growth Arrest and DNA Damage-inducible protein 153 (GADD 153), also known as C/EBP Homologous Protein (CHOP), is a transcription factor that plays a pivotal role in cellular stress responses. It is a member of the C/EBP family and is predominantly expressed when cells undergo endoplasmic reticulum (ER) stress. Under normal cellular conditions, GADD 153 levels are low, but upon the induction of stress, such as during unfolded protein response (UPR) or nutrient deprivation, its expression is markedly upregulated. The upregulation of GADD 153 is indicative of prolonged ER stress and can lead to cellular pathways that result in apoptosis. Therefore, GADD 153 acts as a pro-apoptotic factor, making it a crucial player in determining cell fate under stress conditions.
GADD 153 inhibitors are chemical compounds specifically designed to downregulate or suppress the activity or expression of GADD 153. These inhibitors can act by directly interacting with GADD 153 or by modulating upstream signaling pathways responsible for its induction. By mitigating the function or levels of GADD 153, these inhibitors can effectively reduce the pro-apoptotic effects associated with excessive ER stress, offering protection to cells under adverse conditions. The development and study of GADD 153 inhibitors provide valuable insights into the intricate mechanisms governing cellular responses to stress. These compounds can serve as essential tools for researchers aiming to elucidate the precise roles of GADD 153 in various physiological and pathological contexts, paving the way for a deeper understanding of stress response mechanisms at the cellular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $53.00 $136.00 $418.00 | 10 | |
Acts as a chemical chaperone, reducing ER stress and subsequently down-regulating CHOP expression. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
This bile acid reduces ER stress, potentially leading to decreased CHOP expression. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
By inhibiting dephosphorylation of eIF2α, it can reduce ER stress and CHOP expression. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $102.00 $468.00 $832.00 $4162.00 $7283.00 | 2 | |
It enhances eIF2α phosphorylation, reducing protein synthesis and ER stress, thus potentially reducing CHOP expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
This compound can reduce oxidative stress, which may lead to decreased ER stress and reduced CHOP expression. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
As an antioxidant, it might reduce oxidative stress, potentially down-regulating CHOP. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Its antioxidant properties might reduce oxidative stress-induced CHOP expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate several signaling pathways, potentially reducing ER stress and CHOP expression. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Known to reduce ER stress, potentially leading to a decrease in CHOP expression. | ||||||
Exendin-4 | 141758-74-9 | sc-474611 sc-474611A | 500 µg 1 mg | $146.00 $198.00 | 1 | |
This compound can reduce ER stress, which in turn might down-regulate CHOP. | ||||||