Gα olf Activators
Gα olf activators are molecules that target the Gα olf subunit, a particular G protein subtype that is primarily expressed in olfactory sensory neurons. G proteins, short for guanine nucleotide-binding proteins, play a pivotal role in signal transduction pathways inside cells. They are involved in transmitting signals from various stimuli outside a cell to its interior, initiating a cascade of downstream effects. The G protein-coupled receptors (GPCRs), a large family of cell surface receptors, are key players in these pathways. When a GPCR is activated by a ligand or external stimulus, it undergoes a conformational change that allows it to activate an associated G protein. This G protein then dissociates into its constituent subunits, including the Gα subunit, which can further influence various downstream effectors in the cell.
The Gα olf subtype, as mentioned, is predominantly found in the olfactory system. Olfactory sensory neurons detect odorants from the environment and translate these chemical signals into electrical signals that the brain can interpret as specific smells. The process begins with odorant molecules binding to specific GPCRs on the olfactory neuron's membrane. Once these GPCRs are activated, they in turn activate the Gα olf subunit, leading to a series of intracellular events that result in the generation of an electrical signal. Gα olf activators, therefore, can influence this olfactory signal transduction pathway by directly activating the Gα olf subunit, modulating the sensitivity or responsiveness of the olfactory system to external odorants. Given the specificity of the Gα olf subtype to the olfactory system, understanding the mechanisms and effects of Gα olf activators offers insights into the intricate workings of our sense of smell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, plays crucial roles in cell differentiation and development. It might influence the differentiation of olfactory neurons, possibly affecting the expression of associated proteins like Gα olf. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP might upregulate various proteins, including potentially Gα olf, in certain cellular contexts. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This glucocorticoid can influence numerous cellular processes, including protein expression. It might impact inflammatory responses in olfactory tissue, indirectly affecting Gα olf levels. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, 5-azacytidine can alter gene expression patterns by affecting DNA methylation. This could potentially influence Gα olf expression in certain contexts. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can modify chromatin structure and influence gene expression. It may have an indirect role in Gα olf expression by affecting chromatin dynamics. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
A glucose analog that inhibits glycolysis, it can stress cells and potentially alter protein expression profiles. It might indirectly influence Gα olf expression in response to metabolic changes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, can alter gene expression. By modifying chromatin dynamics, it could potentially influence Gα olf expression. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO is often used as a solvent in biological experiments. It can influence cellular processes and protein expression in high concentrations, possibly affecting Gα olf. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has various cellular effects, including influencing gene expression. Its impact on signaling pathways could indirectly affect Gα olf expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can influence a variety of cellular processes and has been shown to alter protein expression in certain contexts. This might affect Gα olf expression indirectly. | ||||||