FUZ Inhibitors
FUZ inhibitors generally operate by disrupting crucial cellular signaling pathways. All-trans Retinoic Acid and 5-Fluorouracil can alter the functional activity of FUZ by promoting cellular differentiation or disrupting nucleotide synthesis, respectively. These processes are directly involving FUZ, and their disruption can lead to a reduced requirement for FUZ in cell growth and proliferation or disturb the progression of the cell cycle where FUZ is involved. This method of action effectively disrupts the cell proliferation and differentiation processes, leading to the indirect impairment of FUZ.
Simultaneously, FUZ inhibitors may target various signaling pathways, of which FUZ is a part. Inhibitors such as Staurosporine, Genistein, PD98059, U0126, LY294002, SB203580, SP600125, and Y-27632 are potent inhibitors of various kinases and pathways that reduces the regular functioning of these pathways, thus indirectly inhibiting FUZ. For instance, Staurosporine's inhibition of Protein Kinase C (PKC) and Genistein's inhibition of tyrosine kinases can disrupt signaling pathways requiring the participation of FUZ, leading to its functional inhibition. Therefore, by disrupting these key signaling pathways, the inhibitors can indirectly suppress FUZ's activity.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
All-trans Retinoic Acid is a regulator of cell proliferation and differentiation. It can alter the functional activity of FUZ by promoting cellular differentiation, which is a process directly involving FUZ. This can lead to a reduced requirement for FUZ in cell growth and proliferation. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is a pyrimidine analog that disrupts nucleotide synthetic processes. This can indirectly inhibit FUZ by disturbing the progression of the cell cycle, a process in which FUZ plays a crucial role. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of Protein Kinase C (PKC). By inhibiting PKC, it disrupts downstream signaling pathways that require the participation of FUZ, thus leading to its functional inhibition. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin intercalates into DNA, disrupting the cell cycle. This disruption leads to the indirect inhibition of FUZ by altering the cellular proliferation processes that FUZ is directly involved in. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits topoisomerase II, resulting in DNA damage and cell cycle arrest. This arrest can indirectly inhibit FUZ by affecting the cellular proliferation processes that FUZ directly participates in. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. Its inhibition of tyrosine kinases can disrupt signaling pathways requiring the participation of FUZ, leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK, a kinase directly upstream of the ERK pathway. Inhibiting this pathway can lead to the functional inhibition of FUZ, as FUZ is involved in this pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that disrupts the PI3K/AKT pathway. Given that FUZ is directly involved in this pathway, the disruption by LY294002 can indirectly inhibit FUZ. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a potent inhibitor of p38 MAPK. By inhibiting p38 MAPK, SB203580 can disrupt downstream signaling pathways requiring the participation of FUZ, leading to its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of JNK MAPK. By inhibiting JNK MAPK, SP600125 can disrupt downstream signaling pathways requiring the participation of FUZ, leading to its functional inhibition. | ||||||