FSIP2 Activators
Forskolin, a diterpene, acts upon adenylyl cyclase to raise cAMP levels, which in turn activates PKA, a kinase that can phosphorylate transcription factors modulating gene expression, including genes such as FSIP2. Epigallocatechin gallate, navigates through multiple signaling pathways, potentially altering the transcriptional landscape in which FSIP2 resides. Resveratrol, a polyphenolic compound, engages with sirtuin pathways influencing histone deacetylation, an epigenetic modification that can impact FSIP2 expression.
The DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine changes epigenetic marks, leading to a more open chromatin state and possibly increased FSIP2 transcription. Kinase inhibitors like PD98059, LY294002, Y-27632, SB431542, and SP600125 target MEK, PI3K, ROCK, TGF-β, and JNK, respectively. These interventions alter the cascade of signals that eventually reach the control points of FSIP2 expression or activity. Curcumin and sulforaphane are both capable of influencing various cellular regulators, which may include those affecting FSIP2. ZM-447439, an aurora kinase inhibitor, interferes with spindle assembly and may have implications for FSIP2 activity during cell division.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase, increasing cAMP levels which can enhance PKA activity and influence FSIP2 expression or activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Can affect multiple signaling pathways, potentially modulating FSIP2 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Activates sirtuin pathways, which can affect histone deacetylation and potentially influence FSIP2 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A DNA methyltransferase inhibitor that can lead to hypomethylation and upregulation of genes, possibly including FSIP2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, affecting the ERK pathway and potentially altering the transcriptional regulation of FSIP2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can alter AKT signaling, potentially affecting downstream transcription factors that regulate FSIP2. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor that can impact cytoskeleton organization and signaling, potentially influencing FSIP2 expression. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Inhibits TGF-β receptor I, potentially affecting SMAD signaling and the transcriptional regulation of FSIP2. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which can affect AP-1 activity, potentially influencing FSIP2 transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Can modulate various signaling pathways, potentially upregulating FSIP2 expression. | ||||||