FNDC5 Activators
FNDC5 activators primarily consist of compounds known for their roles in metabolic regulation, anti-inflammatory effects, and antioxidant properties. These chemicals, while not directly interacting with FNDC5, promote its expression or activity through various cellular mechanisms. For instance, resveratrol and berberine activate the AMPK pathway, which is a key regulator of energy metabolism and has been implicated in the upregulation of FNDC5. Similarly, compounds like pioglitazone and troglitazone, as PPAR-γ agonists, modulate lipid and glucose metabolism, indirectly influencing FNDC5 expression.
These activators also include naturally occurring compounds such as curcumin, epigallocatechin gallate, and sulforaphane, which are known for their beneficial health effects. Their ability to enhance FNDC5 expression may be linked to their roles in reducing oxidative stress and inflammation, processes that are closely tied to metabolic health. Caffeine, a widely consumed stimulant, demonstrates the diverse range of compounds that can influence FNDC5, through its effects on lipid metabolism and adenosine receptor antagonism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to upregulate FNDC5 expression. It activates SIRT1, which positively influences FNDC5. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin, a common antidiabetic drug, has been observed to increase FNDC5 expression through AMPK activation. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, a PPAR-γ agonist, indirectly enhances FNDC5 expression, linking to improved metabolic profiles. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is involved in upregulating FNDC5 expression, possibly through its anti-inflammatory effects. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This green tea polyphenol has been associated with increased FNDC5 expression, potentially through antioxidant pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can enhance FNDC5 expression, possibly through its role in inflammation and oxidative stress modulation. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine has been suggested to influence FNDC5 expression, likely via adenosine receptor antagonism and metabolic effects. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid has been shown to influence FNDC5 expression, potentially through retinoic acid receptor-mediated pathways. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone, another PPAR-γ agonist, may increase FNDC5 expression, similar to pioglitazone. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, a compound in cruciferous vegetables, might upregulate FNDC5 expression through NRF2 activation. | ||||||