Fibromodulin Inhibitors
Fibromodulin inhibitors represent a category of compounds or molecules that are specifically designed to target and interact with fibromodulin, a proteoglycan protein found within the extracellular matrix of various tissues in the human body. Fibromodulin, a member of the small leucine-rich proteoglycan (SLRP) family, plays a crucial role in regulating the structure and function of connective tissues such as tendons, ligaments, and cartilage. These inhibitors aim to modulate the activity of fibromodulin, which, in turn, can influence the organization and maintenance of these connective tissues.
The primary function of fibromodulin is to bind to collagen fibers, particularly type I and type II collagen, and modulate their assembly and stability. By doing so, it helps regulate the structural integrity of connective tissues and is involved in processes like tissue repair and remodeling. Fibromodulin inhibitors work by interfering with the interactions between fibromodulin and collagen, disrupting the normal collagen fibrillogenesis process. This disruption can have far-reaching effects on tissue biomechanics and structural organization, making these inhibitors of interest in various research contexts related to tissue engineering, regenerative medicine, and understanding the fundamental biology of connective tissues. Researchers study fibromodulin inhibitors to unravel the intricate mechanisms governing tissue development, homeostasis, and repair, with the hope of discovering novel insights into the maintenance and healing of connective tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a cytidine analog that incorporates into RNA and DNA. It is known to induce DNA demethylation, potentially leading to the downregulation of gene expression, including fibromodulin. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that alters chromatin structure, potentially leading to changes in gene expression, including the inhibition of fibromodulin. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol found in grapes and red wine. It has been shown to modulate various signaling pathways and may lead to the downregulation of fibromodulin expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is the active component of turmeric with anti-inflammatory properties. It modulates multiple signaling pathways and may inhibit fibromodulin expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate is the major catechin in green tea, known for its antioxidant properties. It may modulate signaling pathways and inhibit fibromodulin expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane is a compound found in broccoli and other cruciferous vegetables. It has been shown to modulate gene expression, potentially inhibiting fibromodulin. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties. It may regulate signaling pathways and gene expression, including the inhibition of fibromodulin. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone found in soy. It acts as a tyrosine kinase inhibitor and may influence gene expression, potentially downregulating fibromodulin. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol is crucial for calcium homeostasis and bone metabolism. It also regulates gene expression, and it may influence fibromodulin levels. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide is a reactive oxygen species that can influence cellular signaling and gene expression, potentially leading to the downregulation of fibromodulin. | ||||||