Fibromodulin Antibody (H-11): sc-166406

Fibromodulin Antibody (H-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects Fibromodulin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Fibromodulin antibody (H-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Fibromodulin is a crucial member of the small leucine-rich proteoglycans (SLRPs) family, which also includes Decorin, Biglycan, and Lumican, and plays a significant role in the organization of the extracellular matrix. Fibromodulin is primarily located in the extracellular matrix of connective tissues, particularly in articular cartilage, tendon, and ligament, where Fibromodulin is essential for maintaining structural integrity and facilitating cellular interactions. Fibromodulin influences collagen fibril formation by regulating the spacing and thickness of collagen fibers, which is vital for the mechanical properties of tissues. The human Fibromodulin gene is located on chromosome 1q32 and encodes a protein consisting of 376 amino acids, characterized by a central region of leucine-rich repeats flanked by disulfide-linked terminal domains. Fibromodulin′s ability to bind collagen and interact with transforming growth factor-beta (TGF-beta) underscores Fibromodulin′s importance in tissue repair and fibrosis, making Fibromodulin monoclonal antibody (H-11) a valuable tool for researchers studying connective tissue dynamics and related pathologies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Fibromodulin Antibody (H-11) References:

1. The small proteoglycan fibromodulin is expressed in mitotic, but not in postmitotic fibroblasts.  |  Petri, JB., et al. 1999. Mol Cell Biol Res Commun. 1: 59-65. PMID: 10329479
2. Small proteoglycans of normal adult human kidney: distinct expression patterns of decorin, biglycan, fibromodulin, and lumican.  |  Schaefer, L., et al. 2000. Kidney Int. 58: 1557-68. PMID: 11012890
3. Small proteoglycans in human diabetic nephropathy: discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lumican, and fibromodulin.  |  Schaefer, L., et al. 2001. FASEB J. 15: 559-61. PMID: 11259366
4. Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase.  |  Kalamajski, S., et al. 2016. J Biol Chem. 291: 7951-60. PMID: 26893379
5. The role of fibromodulin in cancer pathogenesis: implications for diagnosis and therapy.  |  Pourhanifeh, MH., et al. 2019. Cancer Cell Int. 19: 157. PMID: 31198406
6. The role of fibromodulin in inflammatory responses and diseases associated with inflammation.  |  Zhao, F., et al. 2023. Front Immunol. 14: 1191787. PMID: 37483637
7. Fibromodulin overexpression drives oral squamous cell carcinoma via activating downstream EGFR signaling.  |  Xia, L., et al. 2023. iScience. 26: 108201. PMID: 37965134
8. Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration.  |  Tu, T., et al. 2023. NPJ Regen Med. 8: 67. PMID: 38092758
9. Transfer RNA-derived small RNA tRF-Glu-CTC attenuates neointimal formation via inhibition of fibromodulin.  |  Jiang, QL., et al. 2024. Cell Mol Biol Lett. 29: 2. PMID: 38172726
10. Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence.  |  Sztrolovics, R., et al. 1994. Genomics. 23: 715-7. PMID: 7851907
11. Structure and deduced amino acid sequence of the human fibromodulin gene.  |  Antonsson, P., et al. 1993. Biochim Biophys Acta. 1174: 204-6. PMID: 8357838
12. Changes with age in the structure of fibromodulin in human articular cartilage.  |  Roughley, PJ., et al. 1996. Osteoarthritis Cartilage. 4: 153-61. PMID: 8895216

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Fibromodulin Antibody (H-11) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Fibromodulin Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Fibromodulin Antibody (H-11) Specifications

Alternate Product Name: FMOD

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 46-59

Epitope Target: Fibromodulin

Epitope Species: human

Product Reactivity/Detection: Fibromodulin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Fibromodulin Antibody (H-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Lumican antibody is Lumican Antibody (B-9): sc-166871.