Fcrl5 Inhibitors
FCRL5 inhibitors represent a class of chemical compounds that target the FCRL5 protein, a member of the Fc receptor-like family of proteins. This family is primarily expressed on the surface of immune cells, particularly B cells. FCRL5 is a receptor known to play a role in modulating the immune response, as it binds to immunoglobulins and is involved in signaling pathways that affect the activity of these immune cells. FCRL5 inhibitors work by specifically binding to this protein and altering its function, which can modulate various downstream signaling cascades within the immune system. These inhibitors typically function by preventing the natural ligands of FCRL5 from interacting with the receptor, thereby altering immune cell responses and the associated intracellular signaling networks.
Structurally, FCRL5 inhibitors can be diverse, depending on their specific binding characteristics and mechanisms of action. Some may act as small molecules that interfere with receptor-ligand interactions, while others might be designed to disrupt conformational changes in the FCRL5 protein. The development of these inhibitors often involves detailed biochemical studies to understand the binding affinity and specificity for FCRL5, as well as their ability to selectively modulate the signaling pathways associated with this receptor. As a result, these compounds are valuable tools in exploring the role of FCRL5 in immune cell biology, and their design is typically driven by the need to precisely interfere with protein-protein interactions that define immune cell function and regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor could hypothetically lead to hypomethylation of the Fcrl5 gene promoter, potentially resulting in its downregulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylases, Trichostatin A may cause an increase in acetylation levels around the Fcrl5 gene, leading to the suppression of its transcription. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid might decrease histone deacetylase activity specifically at the Fcrl5 gene locus, causing an alteration in the chromatin structure that leads to reduced Fcrl5 gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, by inhibiting histone deacetylases, could induce hyperacetylation of histones at the Fcrl5 gene, which might repress its expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid's inhibition of histone deacetylase activity could lead to hyperacetylation of histones at the Fcrl5 gene locus, potentially decreasing its transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine might specifically target the Fcrl5 gene's DNA methylation, leading to a reduction in methylation status and subsequent transcriptional downregulation. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
By interfering with transcription factor binding to the Fcrl5 gene promoter, Mithramycin A could directly decrease the transcription initiation of the Fcrl5 gene. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram could indirectly lead to the stabilization of factors that repress the Fcrl5 gene transcription, effectively reducing its expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid could directly repress the transcriptional activity of the Fcrl5 gene by altering the activity of retinoic acid receptor-bound complexes at the Fcrl5 promoter. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
By inhibiting dihydrofolate reductase, Methotrexate could decrease the availability of thymidylate, leading to a lower transcription rate of rapidly dividing cells, which may include cells expressing Fcrl5. | ||||||