FBXW17 Activators
FBXW17 Activators are a class of chemical compounds that influence various cellular signaling pathways, leading to the enhanced functional activity of FBXW17. Forskolin, by elevating cAMP levels, activates PKA, which can phosphorylate proteins that may then serve as substrates for FBXW17 within the SCF ubiquitin ligase complex. Similarly, ionomycin, through its action as a calcium ionophore, increases intracellular calcium levels, which can activate calmodulin-dependent kinases and subsequently result in the phosphorylation of proteins. These phosphorylated proteins could be preferentially targeted by FBXW17. Phorbol esters such as PMA activate PKC, which phosphorylates proteins and potentially exposes degrons that are recognized by FBXW17, hence facilitating the ubiquitination process.
Proteasome inhibitors like MG132 and lactacystin indirectly increase the functional demand for FBXW17 by inhibiting protein degradation and causing the accumulationof polyubiquitinated proteins. The accumulation of these proteins may enhance the ubiquitin ligase activity of FBXW17 as it works to tag additional substrates for degradation. AICAR, through the activation of AMPK, leads to the phosphorylation of downstream targets, which could then be ubiquitinated by FBXW17 as part of energy homeostasis processes. Okadaic acid and calyculin A, as inhibitors of protein phosphatases, increase protein phosphorylation levels, potentially increasing the spectrum of proteins targeted by FBXW17 for ubiquitination. The PI3K/Akt pathway, when inhibited by compounds such as LY294002, can lead to alterations in the phosphorylation and stability of proteins that may intersect with FBXW17's role in ubiquitination. Inhibition of p38 MAPK by SB203580 can similarly influence the pool of proteins that FBXW17 may ubiquitinate. KN-93, by inhibiting CaMKII, affects the phosphorylation status of proteins, which could enhance the ubiquitination capacity of FBXW17.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases intracellular cAMP levels. The rise in cAMP activates protein kinase A (PKA), which can phosphorylate specific substrates. These substrates, once phosphorylated, may be recognized preferentially by FBXW17 as part of its role in the SCF ubiquitin ligase complex, leading to their ubiquitination and degradation. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin acts as a calcium ionophore, increasing intracellular calcium concentration. Elevated calcium can activate calmodulin-dependent kinases, which can phosphorylate proteins that are potentially better substrates for FBXW17-mediated ubiquitination. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates target proteins on serine and threonine residues. These modifications can create or expose degrons that FBXW17 recognizes, thus enhancing its ubiquitin ligase activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), which in turn can phosphorylate downstream substrates. These phosphorylated substrates may then be targeted by FBXW17 for ubiquitination as part of cellular energy homeostasis. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. Inhibition of these phosphatases leads to increased phosphorylation levels of many proteins, which could enhance the substrate recognition and ubiquitination activity of FBXW17. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Similar to okadaic acid, calyculin A inhibits protein phosphatases leading to increased protein phosphorylation. This biochemical change can indirectly enhance the functional activity of FBXW17 by increasing the pool of ubiquitination substrates. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Lactacystin is a specific inhibitor of the proteasome. By preventing protein degradation, lactacystin can indirectly enhance FBXW17's role in targeting specific substrates for ubiquitination. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of the PI3K/Akt pathway, leading to alterations in downstream signaling. This can result in the stabilization of proteins that are targeted by FBXW17, indirectly enhancing its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, which can affect downstream substrate availability. Such changes in the signaling pathway can enhance the functional activity of FBXW17 by altering the phosphorylation status of potential substrates. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). Inhibition of CaMKII affects downstream substrates that could be ubiquitinated by FBXW17, thereby enhancing its activity. | ||||||