FBXO42 Inhibitors
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 inhibits the proteasome, leading to the accumulation of FBXO42 substrate proteins and subsequent degradation of FBXO42 itself, resulting in the inhibition of FBXO42 activity. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 disrupts the interaction between FBXO42 and its substrate proteins, preventing their ubiquitination and degradation, thus inhibiting FBXO42-mediated protein turnover and promoting substrate stabilization. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 inhibits NEDD8-activating enzyme (NAE), leading to the inhibition of cullin neddylation and subsequent inactivation of SCF (Skp1-Cullin-F-box) E3 ligase complexes, including FBXO42, thereby preventing substrate ubiquitination and degradation. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA, inhibiting transcription and leading to the down-regulation of FBXO42 expression, thereby indirectly inhibiting FBXO42 activity. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil inhibits thymidylate synthase, disrupting nucleotide synthesis and leading to the down-regulation of FBXO42 expression, thereby indirectly inhibiting FBXO42 activity. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein synthesis, resulting in the down-regulation of FBXO42 expression, thereby indirectly inhibiting FBXO42 activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the proteasome, leading to the accumulation of FBXO42 substrate proteins and subsequent degradation of FBXO42 itself, resulting in the inhibition of FBXO42 activity. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $112.00 $199.00 $347.00 $683.00 $1336.00 $5722.00 | 12 | |
Eeyarestatin I inhibits the proteasome-associated deubiquitinase (DUB) activity, leading to the stabilization of polyubiquitinated proteins and the down-regulation of FBXO42-mediated protein turnover, thereby inhibiting FBXO42 activity. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
APDC inhibits NF-κB activation, suppressing the expression of FBXO42 target genes involved in inflammation and cell survival, thereby indirectly inhibiting FBXO42 activity. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 inhibits p300/CBP histone acetyltransferase activity, leading to the down-regulation of FBXO42 expression by affecting its transcriptional regulation, thereby indirectly inhibiting FBXO42 activity. | ||||||