FAM69B Activators
Forskolin acts by elevating cAMP levels, thereby activating PKA, which is known to phosphorylate a range of proteins that could intersect with the FAM69B signaling cascade. Ionomycin, by increasing intracellular calcium, triggers a network of calcium-dependent kinases, potentially altering the activity of proteins within the FAM69B regulatory pathway. Phorbol esters such as PMA activate PKC, which has a broad scope in phosphorylating proteins and could therefore affect the signaling pathways that impinge upon FAM69B. Meanwhile, IBMX prevents the degradation of cyclic nucleotides, sustaining the activity of kinases such as PKA and PKG, which could have downstream effects on the regulation of FAM69B. Inhibitors like SB203580 and PD98059, which target p38 MAP kinase and MEK respectively, might recalibrate the activity within MAP kinase pathways, impacting proteins that interact with FAM69B.
Modulation of gene expression is another axis through which FAM69B activity can be influenced. Trichostatin A, an HDAC inhibitor, changes the chromatin landscape, thereby potentially altering the transcriptional program of genes associated with the FAM69B pathway. Spermine modifies ion channel activity and intracellular signaling, which can have implications for the FAM69B regulatory network. LY294002 and SP600125, targeting the PI3K and JNK pathways, effectuate changes in kinase signaling dynamics, potentially affecting FAM69B activity. Rapamycin, by inhibiting mTOR, alters the cellular growth and metabolism framework, which can reverberate through the signaling pathways to influence FAM69B activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX, a non-specific inhibitor of phosphodiesterases, prevents the breakdown of cAMP and cGMP, leading to their accumulation. Elevated levels of these cyclic nucleotides enhance PKA and PKG activity, which can then phosphorylate associated proteins and possibly influence FAM69B activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Calcium acts as a second messenger in various signaling pathways and can activate calmodulin-dependent kinases, which in turn may modulate proteins involved in the FAM69B pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates a wide range of target proteins. PKC-mediated phosphorylation can influence signaling pathways that intersect with FAM69B regulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Inhibition of p38 MAP kinase can cause compensatory effects in other MAPK pathways, such as ERK, which may lead to changes in the phosphorylation state of proteins within the FAM69B pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which prevents the activation of ERK. This can alter the balance of kinase activity, affecting downstream proteins that may interact with or regulate FAM69B. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is an inhibitor of calmodulin-dependent kinase II (CaMKII). Inhibition of CaMKII can shift the balance of calcium-dependent signaling, thereby influencing proteins that can interact with the FAM69B pathway. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine, a polyamine, can modulate ion channel activity and has been shown to influence intracellular signaling pathways, including those involving kinase activity. This modulation can affect proteins that may act upon or regulate the activity of FAM69B. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is an inhibitor of histone deacetylases (HDACs), which leads to changes in chromatin structure and gene expression. Altered gene expression can result in the upregulation of proteins that form part of the FAM69B signaling pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, leading to reduced AKT phosphorylation and activity. This shift in PI3K/AKT signaling can have downstream effects on proteins that interact with or regulate FAM69B. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, altering JNK signaling pathway activity. This change can influence the phosphorylation state of proteins that may regulate FAM69B activity. | ||||||