FAM69A Inhibitors
FAM69A inhibitors comprise a diverse array of chemical compounds that, through distinct mechanisms, lead to the diminishment of FAM69A's functional activity, particularly in neuronal contexts. Riluzole, by inhibiting glutamate release, and memantine, as an NMDA receptor antagonist, both mitigate excitotoxicity, which may lessen the neuronal reliance on FAM69A's role in signaling and maintenance. BAPTA/AM and cyclopiazonic acid, by modulating intracellular calcium levels, may similarly affect FAM69A's activity by altering calcium-dependent signaling pathways. Tetrodotoxin, with its ability to block action potentials, might reduce FAM69A's activity-dependent functions, while concanavalin A could influence pathways involving FAM69A by disrupting glycoprotein-mediated signaling. Carbenoxolone's inhibition of gap junctions and W-7's antagonism of calmodulin, both impinge upon intercellular communication and intracellular signaling, respectively, potentially reducing the functional role of FAM69A.
In addition, chemical inhibitors like KN-93 Phosphate and ML-7 Hydrochloride target key enzymes such as CaMKII and MLCK, respectively, which are integral to the regulation of neuronal signaling and cytoskeletal dynamics, where FAM69A may be implicated. The inhibition of these enzymes could therefore lead to a lessened requirement for FAM69A's activity in these processes. NSC 23766, by inhibiting Rac1, could decrease FAM69A's involvement in actin cytoskeleton organization, and LY 294002, as a PI3K inhibitor, can disrupt the PI3K/AKT pathway, altering the cellular environment and potentially diminishing FAM69A's functionality. These inhibitors, through their targeted actions on various cellular and molecular pathways, collectively contribute to the indirect inhibition of FAM69A, affecting its role in neuronal and cellular processes without directly altering its expression levels.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $189.00 $209.00 $311.00 | 1 | |
Riluzole interacts with the glutamatergic system by inhibiting the release of glutamate, which, in turn, can lead to a decrease in excitotoxicity and a subsequent reduction in neuronal damage. This action may indirectly diminish the functional activity of FAM69A, which is implicated in neuronal development and function. | ||||||
Memantine hydrochloride | 41100-52-1 | sc-203628 | 50 mg | $68.00 | 4 | |
Memantine is an NMDA receptor antagonist that reduces excessive glutamatergic neurotransmission. By dampening this pathway, memantine indirectly decreases the potential for excitotoxic impacts on neurons, thereby potentially reducing the functional demand on FAM69A in neuronal signaling and maintenance. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA/AM is a calcium chelator that buffers intracellular calcium levels. As calcium signaling is crucial for various neuronal processes, regulating calcium dynamics with BAPTA/AM could indirectly lessen the activity of FAM69A, which is thought to be involved in neuronal signaling pathways. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $117.00 $357.00 $928.00 | 17 | |
Concanavalin A binds to and cross-links specific glycoproteins on the cell surface, influencing cell signaling and communication. This action can potentially disrupt cellular processes that rely on glycoprotein functions, which may include pathways where FAM69A is active, indirectly diminishing its activity. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic acid is an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to altered calcium homeostasis. Given the importance of calcium signaling in neuronal function, this disruption can indirectly impact the activity of FAM69A in calcium-dependent signaling pathways. | ||||||
Carbenoxolone disodium | 7421-40-1 | sc-203868 sc-203868A sc-203868B sc-203868C | 1 g 5 g 10 g 25 g | $45.00 $197.00 $351.00 $759.00 | 1 | |
Carbenoxolone is a gap junction inhibitor that disrupts intercellular communication. FAM69A, given its potential role in neuronal processes, may be indirectly affected by the reduction in gap junction-mediated signaling, leading to diminished functional activity. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
W-7 is a calmodulin antagonist that impairs calmodulin-mediated signaling pathways. As many neuronal processes, including some that FAM69A may be involved in, are regulated by calmodulin, its inhibition could indirectly reduce FAM69A activity. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). By inhibiting CaMKII, KN-93 Phosphate may indirectly affect the signaling pathways that involve FAM69A, leading to a decrease in its functional activity. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 Hydrochloride is an inhibitor of myosin light chain kinase (MLCK), which is involved in cytoskeletal dynamics. By inhibiting MLCK, ML-7 can alter cellular morphology and motility, potentially diminishing the functional activity of FAM69A as it may be involved in related cellular processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 is a PI3K inhibitor that disrupts PI3K/AKT signaling, a pathway involved in various cellular processes including survival, growth, and metabolism. Inhibition of this pathway could indirectly affect the activity of FAM69A by altering the cellular contexts in which it operates. | ||||||