FAM47C Activators
FAM47C activators encompass a diverse range of compounds that exert their effects through various intracellular signaling mechanisms, ultimately leading to the activation of this specific protein. Certain activators operate by enhancing the production of cyclic AMP, an important second messenger that activates protein kinase A. Once activated, this kinase can phosphorylate target proteins, including FAM47C, thereby modulating its activity. Another set of activators works through the manipulation of intracellular calcium levels. By increasing calcium concentrations, these compounds can stimulate calcium-dependent kinases, which are capable of phosphorylating a broad spectrum of proteins. Among these potential targets, FAM47C may be phosphorylated resulting in an increase in its functional activity. The alteration of cAMP and calcium levels are critical in the regulation of FAM47C, and these activators leverage this biochemical axis to exert their influence on the protein's activity.
Furthermore, some activators indirectly influence the activity of FAM47C through the modulation of other signaling pathways known to intersect with the functional pathways of FAM47C. For instance, inhibition of certain receptors can disrupt downstream signaling cascades, potentially leading to the activation of kinases that may phosphorylate FAM47C. Other activators caninhibit enzymes responsible for the degradation of key signaling molecules, thereby sustaining the activity of kinases that can act on FAM47C, enhancing its activity. Additionally, certain activators interact with G protein-coupled receptors to modulate adenylate cyclase activity, which can have downstream effects on the protein's phosphorylation state.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A synthetic catecholamine that acts as an agonist for beta-adrenergic receptors, leading to the activation of adenylyl cyclase and a subsequent rise in cAMP levels. This cascade can enhance PKA activity, which may subsequently phosphorylate and activate FAM47C. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A diester of phorbol that activates protein kinase C (PKC). PKC can phosphorylate target proteins, potentially including FAM47C, resulting in increased protein activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore that raises intracellular calcium levels, which can activate calcium-dependent kinases such as calmodulin-dependent kinase (CaMK). CaMK can phosphorylate various proteins, which may include FAM47C, leading to its activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cell-permeable cAMP analog that resists degradation by phosphodiesterases and activates PKA. Activated PKA may phosphorylate FAM47C, thereby increasing its activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that increases intracellular calcium concentration, potentially activating calcium-dependent proteins and kinases that could phosphorylate and activate FAM47C. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases that prevents cAMP degradation, leading to elevated PKA activity. PKA could then phosphorylate and activate FAM47C. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
An organic nitrogenous compound that binds to histamine receptors and can activate phospholipase C (PLC), leading to PKC activation. PKC might then phosphorylate and activate FAM47C. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
A cardiac glycoside that inhibits the Na+/K+ ATPase, leading to alterations in intracellular ion concentrations and activation of signal transduction pathways that could involve kinases phosphorylating and activating FAM47C. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
A form of vitamin B3 that binds to its receptor, GPR109A, leading to the inhibition of adenylate cyclase activity and modulation of downstream signaling pathways. This modulation may result in activation of kinases that could phosphorylate and activate FAM47C. | ||||||