FAM47C Inhibitors
FAM47C inhibitors encompass a diverse array of compounds that exert their effects through the interference of specific cellular signaling pathways in which FAM47C is implicated. The inhibition of kinase activity by certain molecules can perturb kinase-dependent signaling, consequently leading to the functional suppression of FAM47C. For instance, the blocking of mTOR signaling pathways not only hampers overall protein synthesis but also specifically diminishes the activity of proteins like FAM47C. Similarly, the obstruction of PI3K/Akt and MAPK/ERK pathways by dedicated inhibitors can lead to a decrease in phosphorylation events, which are critical for maintaining the functional state of FAM47C. Such targeted disruptions serve to dampen the activity of FAM47C by hindering its participation in signaling cascades that modulate various cellular functions.
Additionally, the modulation of FAM47C activity can be achieved by inhibitors that act on proteins regulating the cell cycle and protein degradation pathways. Compounds that inhibit proteasome activity indirectly lead to alterations in the functional expression of FAM47C by impacting its degradation mechanism. Furthermore, the inhibition of receptor tyrosine kinases, Aurora kinases, and CDK4/6 alters the regulation of cell proliferation and division, processes in which FAM47C may play a role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor that through inhibition of various kinases can impact kinase-dependent signaling pathways in which FAM47C is involved, leading to its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can downregulate protein synthesis pathways, including those associated with FAM47C, thereby reducing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that can attenuate the PI3K/Akt pathway, resulting in reduced phosphorylation and activity of proteins downstream, including FAM47C. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MEK inhibitor that prevents the activation of the MAPK/ERK pathway, which could be necessary for the full activity of FAM47C. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that can reduce the activity of proteins regulated by the p38 MAPK pathway, potentially affecting FAM47C function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor which can diminish the JNK signaling pathway's role in cellular processes, potentially leading to reduced FAM47C activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor which can lead to decreased activation of AKT, affecting the cellular processes in which FAM47C is involved. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
An AKT inhibitor that prevents its signaling, which can be crucial for the regulation and function of FAM47C. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that can indirectly decrease the functional activity of FAM47C by affecting its degradation pathway. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
A receptor tyrosine kinase inhibitor that can affect signaling pathways regulating cellular processes, including those involving FAM47C. | ||||||