FAM40A Inhibitors
Chemical inhibitors of FAM40A function through various mechanisms that intersect with the protein's role in cellular processes. Staurosporine and Gö 6983, for example, are broad-spectrum kinase inhibitors that disrupt the function of protein kinases which regulate the STRIPAK complex, to which FAM40A belongs. By inhibiting these kinases, the regulatory control over the STRIPAK complex is compromised, leading to the functional inhibition of FAM40A. Similarly, PP2, a selective inhibitor of the Src family of tyrosine kinases, can inhibit FAM40A by preventing the tyrosine phosphorylation-dependent signal transduction pathways which might otherwise modulate the STRIPAK complex's activity. On a different front, Y-27632, a ROCK inhibitor, can disrupt the actin cytoskeleton dynamics, indirectly leading to an inhibition of FAM40A, which is implicated in cytoskeletal organization.
Moreover, U0126 and PD98059, both inhibitors of MEK, indirectly inhibit FAM40A by interfering with the MAPK/ERK pathway, a critical signaling route that FAM40A may influence. LY294002 and Wortmannin, as PI3K inhibitors, disrupt the AKT signaling pathway, thereby potentially altering FAM40A function due to its role in signal transduction related to cell survival and growth. Inhibition of p38 MAP kinase by SB203580 also affects the cellular stress response, which can lead to the functional inhibition of FAM40A due to its potential interactions with stress-responsive cellular components. JNK inhibitor SP600125 disrupts apoptosis and proliferation signaling pathways, which are other avenues through which FAM40A function can be indirectly inhibited. Lastly, BAY 11-7082 and Bisindolylmaleimide I target NF-κB and PKC, respectively, both of which are involved in regulation and signaling pathways that are essential for the proper function of the STRIPAK complex and thus FAM40A. By targeting these molecules, the function of FAM40A is indirectly inhibited by disrupting the downstream signaling pathways and cellular processes that rely on FAM40A's activity within the STRIPAK complex.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. FAM40A is involved in the STRIPAK complex, which is regulated by kinases. Inhibition of these kinases can lead to the disruption of the STRIPAK complex function, and thereby functionally inhibit FAM40A. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. Since tyrosine phosphorylation can regulate the activity of proteins involved in the STRIPAK complex, PP2 can inhibit the function of FAM40A by impairing the signal transduction that would otherwise modulate its activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK (Rho-associated protein kinase). Since ROCK can influence actin cytoskeleton dynamics and FAM40A is associated with cellular structure regulation, inhibiting ROCK can indirectly inhibit the function of FAM40A by destabilizing actin cytoskeleton interactions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is involved in the AKT signaling pathway, which is crucial for cell survival and growth. As FAM40A is implicated in cellular structure and signal transduction, inhibiting PI3K can indirectly inhibit the function of FAM40A by disrupting downstream signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, and it operates in a similar manner to LY294002. By inhibiting PI3K, it can disrupt the AKT signaling pathway and consequently indirectly inhibit the function of FAM40A. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Inhibition of p38 MAP kinase can affect the cellular response to stress and cytokines. Since FAM40A may interact with components regulated by p38 MAP kinase, its function can be indirectly inhibited by this chemical. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAP kinase family. JNK pathway is involved in the regulation of apoptosis and cellular proliferation. FAM40A's function can be indirectly inhibited by blocking JNK signaling that may affect the STRIPAK complex activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that blocks the MAPK/ERK pathway. By inhibiting MEK, PD98059 can indirectly inhibit the function of FAM40A by altering signaling pathways that control cellular processes in which FAM40A is involved. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a pan-protein kinase C (PKC) inhibitor. Given the role of PKC in a plethora of signaling pathways, including those related to the STRIPAK complex, inhibition of PKC can indirectly inhibit the function of FAM40A by disrupting associated signaling. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation. NF-κB is a transcription factor that can regulate genes involved in the STRIPAK complex. By inhibiting NF-κB, BAY 11-7082 can indirectly inhibit the function of FAM40A by affecting gene regulation. | ||||||