FAM40A Activators
The first class of FAM40A activators includes compounds that enhance the level of cAMP (Forskolin, Rolipram, 8-Bromo-cAMP, IBMX, Dibutyryl-cAMP, Epinephrine, Isoproterenol, NECA, BAY 60-6583, Salbutamol). cAMP is a secondary messenger that is important for many biological responses, and its level is regulated by adenylyl cyclase, the enzyme that synthesizes cAMP, and phosphodiesterases (PDEs) that degrade it. Some of these compounds directly activate adenylyl cyclase (Forskolin, Epinephrine, Isoproterenol, NECA, BAY 60-6583, Salbutamol), while others inhibit PDEs (Rolipram, IBMX), leading to increased cAMP levels. As part of the STRIPAK complex, FAM40A interacts with cAMP-dependent protein kinases (PKA). This interaction implies that an increase in cAMP levels could enhance the functional activity of FAM40A by increasing its interaction with PKA.
The second class of FAM40A activators includes compounds that increase the level of another secondary messenger, cGMP (BAY 73-6691, Sildenafil). cGMP is also a crucial mediator of various biological responses and its level is regulated by guanylyl cyclase, the enzyme that synthesizes cGMP, and phosphodiesterases (PDEs) that degrade it. In this group, BAY 73-6691 inhibits PDE9, while Sildenafil inhibits PDE5, both leading to increased cGMP levels. Similar to the interaction with cAMP-dependent kinases, FAM40A, as part of the STRIPAK complex, also interacts with cGMP-dependent protein kinases (PKG). Hence, an increase in cGMP levels could also enhance the functional activity of FAM40A by increasing its interaction with PKG. Therefore, both cAMP and cGMP enhancing compounds can be considered as FAM40A activators.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which breaks down cAMP. Thus, Rolipram increases cAMP levels indirectly, potentially enhancing the activity of FAM40A due to its interaction with cAMP-dependent protein kinases. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog. As FAM40A is part of the STRIPAK complex interacting with cAMP-dependent protein kinases, the increased intracellular cAMP levels can enhance the functional activity of FAM40A. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. Increased cAMP levels can enhance the functional activity of FAM40A due to its interaction with cAMP-dependent protein kinases. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog. By increasing intracellular cAMP levels, it can enhance the functional activity of FAM40A which interacts with cAMP-dependent protein kinases as part of the STRIPAK complex. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to adrenergic receptors, leading to activation of adenylyl cyclase and increased cAMP levels. This can enhance the functional activity of FAM40A due to its interaction with cAMP-dependent protein kinases. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that increases cAMP levels. As FAM40A interacts with cAMP-dependent protein kinases, increased cAMP levels can enhance the functional activity of FAM40A. | ||||||
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
BAY 60-6583 is an adenosine A2B receptor agonist. Activation of this receptor leads to increased cAMP levels, potentially enhancing the functional activity of FAM40A. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol is a beta2-adrenergic receptor agonist that leads to increased cAMP levels. Increased cAMP can enhance the functional activity of FAM40A due to its interaction with cAMP-dependent kinases. | ||||||
BAY 73-6691 | 794568-92-6 | sc-252407 | 5 mg | $247.00 | 2 | |
BAY 73-6691 is a selective inhibitor of PDE9, leading to increased cGMP levels. As part of the STRIPAK complex, FAM40A interacts with cGMP-dependent protein kinases and increased cGMP levels can enhance its functional activity. | ||||||