FAM171B Inhibitors
FAM171B inhibitors are a class of chemical compounds designed to selectively inhibit the activity of the FAM171B protein, which is involved in a variety of cellular functions, including protein-protein interactions and signal transduction pathways. FAM171B is part of a family of proteins that have been implicated in regulating specific cellular processes, though the precise mechanisms of its function are still being explored. Inhibitors of FAM171B are typically small molecules that bind to the protein at key functional sites, such as the active site or an allosteric site, thereby preventing the protein from interacting with its natural substrates or binding partners. This inhibition is achieved by disrupting the normal structural conformation of FAM171B, which is necessary for its biological activity.
The development of FAM171B inhibitors involves a detailed understanding of the protein's structure and the specific molecular interactions that govern its activity. Researchers utilize techniques such as X-ray crystallography, NMR spectroscopy, and molecular docking studies to identify potential binding sites and to design inhibitors that can effectively target these sites. The chemical structures of FAM171B inhibitors are diverse, often featuring functional groups that are capable of forming strong interactions with the protein, such as hydrogen bonds, van der Waals forces, and hydrophobic contacts. Additionally, these inhibitors are designed to be highly selective for FAM171B, minimizing the potential for off-target effects on other proteins with similar structures. This selectivity is achieved through careful optimization of the inhibitor's molecular features to match the unique characteristics of FAM171B's binding sites. The ultimate goal in designing FAM171B inhibitors is to create compounds that can modulate the protein's function with high precision, allowing researchers to study its role in cellular processes more effectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a specific inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, it reduces the downstream signaling which includes the Akt pathway, a pathway where FAM171B is involved. Inhibition of this pathway can lead to the functional inhibition of FAM171B's role in cell signaling. | ||||||
PD 168393 | 194423-15-9 | sc-222138 | 1 mg | $162.00 | 4 | |
PD168393 is an irreversible inhibitor of EGFR tyrosine kinase. By blocking EGFR tyrosine kinase, it disrupts the EGFR signaling pathway. FAM171B, through its involvement in this pathway, would be functionally inhibited due to the cessation of EGFR-mediated phosphorylation events. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another PI3K inhibitor, similar to Wortmannin. It halts the PI3K-Akt signaling cascade, thereby preventing any downstream effects on proteins that are regulated by this pathway, including the functional activity of FAM171B. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2 which are critical components of the MAPK/ERK pathway. By inhibiting MEK1/2, U0126 prevents the activation of ERK, thereby inhibiting the signaling cascade that could include FAM171B as a downstream effector. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. Inhibition of p38 MAP kinase can disrupt signaling pathways that are involved in the regulation of FAM171B, leading to its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor, and by inhibiting mTOR, it blocks one of the central regulators of cell growth and proliferation. Since mTOR can control various proteins within its signaling network, including FAM171B, its inhibition can lead to the functional inhibition of FAM171B. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). JNK is part of stress-activated pathways that can modulate various proteins, including FAM171B. Inhibition of JNK results in the functional inhibition of downstream proteins regulated by this pathway, including FAM171B. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. Inhibiting Src kinases can disrupt various cellular processes, including those involving FAM171B, leading to its functional inhibition through disruption of Src-dependent signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor, similar to U0126. It inhibits the MAPK/ERK pathway upstream, which would prevent the activation of proteins involved in this pathway, including FAM171B, leading to its functional inhibition. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC). PKC is involved in a variety of signaling pathways, including those that may regulate FAM171B. Inhibition of PKC can result in the functional inhibition of FAM171B due to the disruption of PKC-mediated signaling events. | ||||||