FAM171B Activators
Chemical activators of FAM171B can instigate a series of intracellular signaling cascades that culminate in the activation of this protein. Phorbol 12-myristate 13-acetate, for instance, directly stimulates protein kinase C (PKC), which is well-known for its role in the phosphorylation of target proteins. When PKC is activated by this compound, it can phosphorylate FAM171B, leading to its functional activation. Similarly, forskolin raises the levels of intracellular cAMP, thereby activating protein kinase A (PKA). The activation of PKA can also result in the phosphorylation and subsequent activation of FAM171B. Ionomycin operates through a different mechanism, elevating intracellular calcium levels and thus activating calmodulin-dependent kinases, which, in turn, are capable of phosphorylating FAM171B. Epidermal Growth Factor (EGF) engages its receptor to initiate the MAPK/ERK pathway, which is implicated in the phosphorylation of a multitude of proteins, including those associated with FAM171B.
Insulin triggers the PI3K/AKT signaling pathway, leading to the activation of AKT, which can phosphorylate and activate FAM171B. Hydrogen peroxide serves as a signaling molecule, which can modulate the activity of kinases that phosphorylate FAM171B. Anisomycin is known to activate stress-activated MAPK pathways, such as JNK and p38, which can directly phosphorylate and activate FAM171B. Dibutyryl-cAMP, a synthetic analog of cAMP, can similarly activate PKA, leading to the phosphorylation of FAM171B. Inhibitors of protein phosphatases like Okadaic Acid and Calyculin A prevent the dephosphorylation of proteins, thus maintaining FAM171B in an activated state. Bisindolylmaleimide I, although primarily a PKC inhibitor, under certain conditions can paradoxically activate PKC, which may phosphorylate FAM171B. Lastly, S-Nitroso-N-acetylpenicillamine (SNAP) releases nitric oxide that activates soluble guanylate cyclase, and the subsequent activation of PKG can also lead to the phosphorylation and activation of FAM171B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate activates protein kinase C (PKC), which is implicated in the phosphorylation of many proteins, including FAM171B. PKC-mediated phosphorylation of FAM171B would result in its functional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium concentration, which can activate calmodulin-dependent kinases. These kinases can phosphorylate proteins within the signaling pathways that FAM171B is involved, thus activating FAM171B. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin engages its receptor, triggering the PI3K/AKT signaling pathway. AKT can phosphorylate substrates involved in the same pathway as FAM171B, which would result in the activation of FAM171B. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide acts as a signaling molecule that can activate kinases which target proteins for phosphorylation. These phosphorylation events can include proteins within the same pathway as FAM171B, leading to its activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates stress-activated MAPK pathways, including JNK and p38, which phosphorylate proteins within the signaling pathways of FAM171B. This phosphorylation is a mechanism for the activation of FAM171B. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA. PKA then phosphorylates proteins within the pathways that include FAM171B, therefore activating FAM171B. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a phosphatase inhibitor that prevents dephosphorylation of proteins. By maintaining phosphorylation, Okadaic Acid can ensure the active state of proteins in the FAM171B pathway, leading to the sustained activation of FAM171B. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, similar to Okadaic Acid, inhibits phosphatases, thereby preserving the phosphorylation state of proteins within the FAM171B pathway. This preservation of the phosphorylated form leads to activation of FAM171B. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I, though primarily a PKC inhibitor, in certain conditions can activate PKC. Activated PKC can phosphorylate proteins within the signaling pathways involving FAM171B, thus leading to the activation of FAM171B. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $74.00 $114.00 $374.00 | 18 | |
S-Nitroso-N-acetylpenicillamine (SNAP) releases nitric oxide which activates soluble guanylate cyclase, leading to the activation of PKG. PKG then phosphorylates proteins within the signaling pathways including FAM171B, resulting in the activation of FAM171B. | ||||||