FAM111B Activators
FAM111B activators include compounds that interfere with the phosphoinositide 3-kinase (PI3K)/AKT pathway, one of the most critical cell signaling systems. These compounds (LY294002, Wortmannin, Quercetin, Dactolisib, Perifosine, PI-103, ZSTK474, Apigenin) inhibit PI3K, a key upstream kinase in the pathway, or AKT, the main downstream effector. By inhibiting these kinases, they prevent the phosphorylation of multiple downstream targets. One such target is FAM111B, the activity of which is enhanced when it is not phosphorylated. Thus, these compounds, through their inhibitory effects on the PI3K/AKT pathway, can enhance the functional activity of FAM111B.
Additional FAM111B activators include compounds that inhibit mTOR (Rapamycin, Dactolisib, PI-103), a kinase that regulates cell growth and protein synthesis, or p70 S6 kinase (AT7867), a downstream target of mTOR. By inhibiting these kinases, these compounds reduce protein synthesis and cell growth. This is beneficial for FAM111B, which is involved in DNA replication and cell cycle progression. Reduced protein synthesis means that there is less competition for resources, allowing FAM111B to function more effectively. Similarly, slower cell growth means that FAM111B has more time to complete its functions. Thus, these compounds, throughtheir inhibitory effects on mTOR or p70 S6 kinase, can enhance the functional activity of FAM111B. Other FAM111B activators include compounds that specifically target AKT (Perifosine, Triciribine, A-443654, AT7867). AKT, a serine/threonine kinase, is a central component of the PI3K/AKT signaling pathway. Inhibition of AKT leads to reduced phosphorylation of its downstream targets. FAM111B, being a target of AKT, experiences enhanced functional activity when AKT is inhibited.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). This inhibition prevents the formation of PIP3 from PIP2, thereby reducing the activation of AKT. This decreases the phosphorylation of downstream targets, one of which is FAM111B, leading to its enhanced functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another potent PI3K inhibitor. By blocking PI3K activity, it prevents AKT activation, which in turn limits the phosphorylation of its targets, including FAM111B. This results in enhanced functional activity of FAM111B. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid known to inhibit PI3K and AKT. By inhibiting these kinases, it reduces phosphorylation of downstream proteins, including FAM111B, leading to an increase in FAM111B functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. Inhibition of mTOR leads to a reduction in protein synthesis and cell growth, which can enhance the activity of FAM111B. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $207.00 | 8 | |
Dactolisib is a dual inhibitor of PI3K and mTOR. By inhibiting these pathways, this compound can enhance the functional activity of FAM111B. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine is a lipid-based AKT inhibitor. By inhibiting AKT, perifosine reduces the phosphorylation of downstream targets, including FAM111B, which enhances its functional activity. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is a specific AKT inhibitor. By inhibiting AKT, it reduces phosphorylation of its targets, including FAM111B, enhancing its activity. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $32.00 $128.00 | 3 | |
PI-103 is a dual inhibitor of PI3K and mTOR. By blocking these pathways, PI-103 can enhance the functional activity of FAM111B. | ||||||
A-443654 | 552325-16-3 | sc-507339 | 1 mg | $140.00 | ||
A-443654 is a specific AKT inhibitor. By inhibiting AKT, it reduces phosphorylation of its targets, leading to increased functional activity of FAM111B. | ||||||
ZSTK 474 | 475110-96-4 | sc-475495 | 5 mg | $75.00 | ||
ZSTK474 is a selective PI3K inhibitor. By inhibiting PI3K, it reduces AKT activation and the subsequent phosphorylation of downstream targets, including FAM111B, enhancing its functional activity. | ||||||