Molecular structure of A-443654, CAS Number: 552325-16-3
A-443654 (CAS 552325-16-3)
Alternate Names:
(2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine
CAS Number:
552325-16-3
Molecular Weight:
397.5
Molecular Formula:
C24H23N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
A-443654 (CAS 552325-16-3) References
- Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. | Gallia, GL., et al. 2009. Mol Cancer Ther. 8: 386-93. PMID: 19208828
- Inhibitor hijacking of Akt activation. | Okuzumi, T., et al. 2009. Nat Chem Biol. 5: 484-93. PMID: 19465931
- Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells. | de Frias, M., et al. 2009. Haematologica. 94: 1698-707. PMID: 19815839
- Context-dependent antagonism between Akt inhibitors and topoisomerase poisons. | Gálvez-Peralta, M., et al. 2014. Mol Pharmacol. 85: 723-34. PMID: 24569089
- TORC2: a novel target for treating age-associated memory impairment. | Johnson, JL., et al. 2015. Sci Rep. 5: 15193. PMID: 26489398
- Aurora kinase A promotes hepatitis B virus replication and expression. | Jeong, GU. and Ahn, BY. 2019. Antiviral Res. 170: 104572. PMID: 31376425
- A new advanced in silico drug discovery method for novel coronavirus (SARS-CoV-2) with tensor decomposition-based unsupervised feature extraction. | Taguchi, YH. and Turki, T. 2020. PLoS One. 15: e0238907. PMID: 32915876
- The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy. | Gandelman, M., et al. 2021. J Biol Chem. 297: 101191. PMID: 34520759
- Machine Learning Screens Potential Drugs Targeting a Prognostic Gene Signature Associated With Proliferation in Hepatocellular Carcinoma. | Liu, J., et al. 2022. Front Genet. 13: 900380. PMID: 35836576
- Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling. | Zhong, YT., et al. 2023. J Orthop Translat. 40: 132-146. PMID: 37457309
Inhibitor of:
DIP2C, EG625424, FAM23B, FNDC1, HEPN1, Mnk1, Morc4, NICE4, NKIAMRE, NKR-P1F, Olfr584, PI 4-kinase II β, RN-tre, Sm F, Sval1, Tap42, TTP-αL, ZCCHC16, ZNF354B, ZNF585A, and ZNF763.Activator of:
1500002O20Rik, Akt1, C23, CD69, DDX57, FAM111B, FANCI, FTS, MOV10, NYAP2, and PIK3IP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-443654, 1 mg | sc-507339 | 1 mg | $140.00 |