FAM111B Inhibitors
Chemical inhibitors of FAM111B can achieve functional inhibition through their action on the cell cycle, which is a biological process where FAM111B plays a critical role. Alsterpaullone, Roscovitine, Purvalanol A, Olomoucine, Indirubin, Flavopiridol, Dinaciclib, and Milciclib are all inhibitors of cyclin-dependent kinases (CDKs), a group of enzymes that are pivotal for the progression of cells through the cell cycle. FAM111B is implicated in the regulation of DNA replication and chromatin organization, which are processes that are tightly coupled to the cell cycle. By inhibiting CDKs, these chemicals can disrupt the progression of the cell cycle at various checkpoints. This action can impede the activity of FAM111B by preventing the cell cycle-dependent steps that FAM111B is known to regulate. For instance, Flavopiridol and Milciclib can induce a broad inhibition of CDKs, leading to a potential halt in cell cycle phases where FAM111B is necessary for the maintenance of DNA integrity and replication fidelity.
Additionally, chemicals like Harmine, PD0332991, Ribociclib, and AT7519 target specific CDKs or related kinases such as dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). Harmine can inhibit DYRK, a kinase implicated in cell cycle control, thereby affecting the cell cycle and subsequently the functional role of FAM111B. PD0332991 and Ribociclib, by selectively inhibiting CDK4 and CDK6, can alter the cell cycle dynamics, indirectly inhibiting the role of FAM111B in DNA replication and checkpoint control. AT7519, as a multi-CDK inhibitor, can also exert an influence on FAM111B's activity by disrupting the cell cycle and other CDK-dependent processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a known inhibitor of cyclin-dependent kinases (CDKs). FAM111B is implicated in cell cycle regulation. By inhibiting CDKs, Alsterpaullone can disrupt the cell cycle progression, potentially hindering the activity of FAM111B, which is involved in DNA replication and cell cycle control. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is another CDK inhibitor. It can obstruct the cell cycle at specific checkpoints, potentially impeding the function of FAM111B by disrupting the processes in which FAM111B is critical, such as DNA replication and chromatin organization. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A selectively inhibits CDKs and could thereby interfere with the cell cycle, indirectly inhibiting FAM111B activity by impeding the cell cycle-dependent processes that FAM111B is known to regulate. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Olomoucine is a CDK inhibitor that can arrest cell cycle progression. By targeting CDKs, it may diminish the function of FAM111B, as FAM111B is essential for the proper progression of the cell cycle. | ||||||
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $112.00 $515.00 | 4 | |
Indirubin is a potent inhibitor of CDKs and is known to impede cell cycle progression. As FAM111B is involved in cell cycle control, the inhibition of CDKs by Indirubin can indirectly inhibit the functional role of FAM111B. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol broadly inhibits CDKs, which are vital for cell cycle regulation. By inhibiting these kinases, Flavopiridol can disrupt the cell cycle processes that FAM111B is part of, thereby indirectly inhibiting its function. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $242.00 $871.00 | 1 | |
Dinaciclib strongly inhibits multiple CDKs. Given that FAM111B has a role in cell cycle progression, the inhibition of CDKs by Dinaciclib can lead to an indirect functional inhibition of FAM111B by halting cell cycle-dependent activities. | ||||||
Harmine | 442-51-3 | sc-202644 sc-202644A sc-202644B sc-202644C sc-202644D sc-202644E sc-202644F | 250 mg 500 mg 1 g 10 g 50 g 100 g 500 g | $52.00 $102.00 $124.00 $540.00 $1438.00 $2560.00 $11230.00 | 2 | |
Harmine is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK), which plays a role in cell cycle control. The inhibition of DYRK can affect the cell cycle, indirectly impeding FAM111B, which is involved in this process. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
PD0332991, also known as Palbociclib, is a selective inhibitor of CDK4 and CDK6. FAM111B's function in cell cycle progression suggests that disrupting CDK4/6 activity can indirectly inhibit the functional role of FAM111B by affecting cell cycle dynamics. | ||||||
Ribociclib | 1211441-98-3 | sc-507367 | 10 mg | $450.00 | ||
Ribociclib selectively inhibits CDK4 and CDK6. By impeding the function of these CDKs, Ribociclib can indirectly inhibit FAM111B, which requires orderly cell cycle progression for its function in DNA replication and checkpoint control. | ||||||