FADS2 Activators
The chemical class of FADS2 activators encompasses a diverse range of compounds that can enhance the activity of the enzyme Fatty Acid Desaturase 2 (FADS2). FADS2 is crucial in the metabolic pathways of polyunsaturated fatty acids (PUFAs), playing a key role in the introduction of double bonds in fatty acids. This enzyme is integral to the biosynthesis of long-chain PUFAs, including arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. The activation of FADS2, therefore, has significant implications for the metabolism and availability of these essential fatty acids. FADS2 activators can be of various natures, including certain fatty acids themselves, compounds that modify gene expression, and molecules that influence the enzyme's regulatory mechanisms.
These activators often function at the molecular level by either directly interacting with the enzyme or by altering the expression of the FADS2 gene. Some activators might bind to the active site or allosteric sites of the enzyme, inducing conformational changes that enhance enzyme activity. Others might influence the transcriptional machinery, leading to increased production of the FADS2 enzyme. Additionally, certain activators might affect the enzyme's stability, protecting it from degradation, or they may influence the lipid environment in which FADS2 operates, thereby facilitating its activity. The interaction of FADS2 activators with the enzyme is a complex process and can depend on various factors, including the cellular context, the presence of cofactors, and the overall metabolic state of the cell. Understanding the mechanisms by which these activators function is key to comprehending their role in fatty acid metabolism.
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Items 1 to 10 of 14 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $33.00 $63.00 $163.00 $275.00 | 4 | |
Known to modify fatty acid metabolism and may influence FADS2 expression. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516, a PPARδ agonist, activates peroxisome proliferator-activated receptor delta (PPARδ). This activation induces the transcription of genes involved in fatty acid metabolism, indirectly influencing FADS2 expression by promoting a cellular environment conducive to fatty acid synthesis. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMP-activated protein kinase (AMPK) activator. By stimulating AMPK, AICAR enhances cellular energy sensing and metabolism, indirectly activating FADS2 through the modulation of AMPK-mediated signaling pathways that play a role in lipid metabolism. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $253.00 | 1 | ||
A hormone involved in lipid metabolism, might influence FADS2 expression. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate is a PPARα agonist that activates peroxisome proliferator-activated receptor alpha (PPARα). Through this activation, Clofibrate influences lipid metabolism and may indirectly impact FADS2 expression by altering the transcriptional landscape related to fatty acid synthesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound, activates SIRT1, a deacetylase involved in cellular energy homeostasis. Through SIRT1 activation, Resveratrol can modulate metabolic pathways that influence FADS2, providing an indirect means of activation by affecting cellular metabolic processes. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $37.00 $194.00 $64.00 | 5 | |
High glucose levels can influence fatty acid synthesis and might affect FADS2. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate is a pan-PPAR agonist that activates multiple peroxisome proliferator-activated receptors, including PPARα. Its activation of PPARs influences lipid metabolism, potentially indirectly activating FADS2 by modulating the transcriptional regulation of fatty acid synthesis genes. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Regulates lipid metabolism and might influence FADS2 expression. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin is an AMPK activator that indirectly influences FADS2 through its effects on cellular energy metabolism. By activating AMPK, Metformin modulates pathways related to lipid metabolism, providing a potential indirect means of FADS2 activation by altering the cellular environment for fatty acid synthesis. | ||||||