Date published: 2025-10-15

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Linoleic Acid (CAS 60-33-3)

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Alternate Names:
Telfairic Acid; 9-cis,12-cis-Octadecadienoic acid
Application:
Linoleic Acid is a fatty acid with cytotoxic activity that influences the inflammatory process
CAS Number:
60-33-3
Purity:
≥99%
Molecular Weight:
280.44
Molecular Formula:
C18H32O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Linoleic Acid is a fatty acid that has been observed to influence the inflammatory process and regulate the functions of neutrophils. Research has demonstrated that Linoleic Acid has cytotoxic activity and induces cell apoptosis by augmenting cellular oxidant status and inducing mitochondrial dysfunction. Additionally, the compound may act to stimulate the growth of MDA-MB-231 cells, increase the production of thromboxanes and prostaglandins, and reduce the levels of HHT and HETE. Linoleic Acid is an activator of PPAR.


Linoleic Acid (CAS 60-33-3) References

  1. Conjugated linoleic acid: effects on plasma lipids and cardiovascular function.  |  Khosla, P. and Fungwe, TV. 2001. Curr Opin Lipidol. 12: 31-24. PMID: 11176200
  2. Factors affecting conjugated linoleic acid content in milk and meat.  |  Dhiman, TR., et al. 2005. Crit Rev Food Sci Nutr. 45: 463-82. PMID: 16183568
  3. The health implications of changing linoleic acid intakes.  |  Whelan, J. 2008. Prostaglandins Leukot Essent Fatty Acids. 79: 165-7. PMID: 18990554
  4. Dietary free oleic and linoleic acid enhances neutrophil function and modulates the inflammatory response in rats.  |  Rodrigues, HG., et al. 2010. Lipids. 45: 809-19. PMID: 20730605
  5. Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction.  |  Lu, X., et al. 2010. Lipids Health Dis. 9: 106. PMID: 20868498
  6. Linoleic acid inhibits Lactobacillus activity by destroying cell membrane and affecting normal metabolism.  |  Lv, H., et al. 2020. J Sci Food Agric. 100: 2057-2064. PMID: 31875968
  7. Oxidized linoleic acid metabolites maintain mechanical and thermal hypersensitivity during sub-chronic inflammatory pain.  |  Wedel, S., et al. 2022. Biochem Pharmacol. 198: 114953. PMID: 35149052
  8. Linoleic Acid Intake and Physical Function: Pilot Results from the Health ABC Energy Expenditure Sub-Study.  |  Belury, MA., et al. 2022. Adv Geriatr Med Res. 4: PMID: 35368862
  9. Linoleic acid reduces apoptosis via NF-κB during the in vitro development of induced parthenogenic porcine embryos.  |  Lee, DK., et al. 2022. Theriogenology. 187: 173-181. PMID: 35596974
  10. Exploration of the Mechanism of Linoleic Acid Metabolism Dysregulation in Metabolic Syndrome.  |  Wen, Y., et al. 2022. Genet Res (Camb). 2022: 6793346. PMID: 36518097
  11. Linoleic acid, prostaglandin synthesis and chronic renal failure in rats.  |  . 1983. Nutr Rev. 41: 94-6. PMID: 6341898
  12. A comparative study on the effect of cis (oleic, linoleic) and trans (elaidic, linoelaidic) fatty acids on the in vitro prostaglandin biosynthesis in human blood platelets from (1-14C) arachidonic acid.  |  Srivastava, KC. and Awasthi, KK. 1982. Prostaglandins Leukot Med. 9: 669-84. PMID: 6818563
  13. Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro.  |  Rose, DP., et al. 1994. Cancer Res. 54: 6557-62. PMID: 7987856

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Linoleic Acid, 100 mg

sc-200788
100 mg
$33.00

Linoleic Acid, 1 g

sc-200788A
1 g
$63.00

Linoleic Acid, 5 g

sc-200788B
5 g
$163.00

Linoleic Acid, 25 g

sc-200788C
25 g
$275.00