FACL6 Inhibitors
FACL6 inhibitors are a class of chemical compounds designed to specifically inhibit the activity of FACL6, also known as fatty acyl-CoA ligase 6. FACL6 is an enzyme that plays a key role in lipid metabolism by catalyzing the activation of long-chain fatty acids through the formation of fatty acyl-CoA thioesters. This process is essential for various downstream metabolic pathways, including β-oxidation of fatty acids, lipid synthesis, and the regulation of intracellular lipid storage. By inhibiting FACL6, researchers can explore the mechanisms of fatty acid activation and its role in cellular energy balance, lipid homeostasis, and the regulation of metabolic flux.
The mechanism of FACL6 inhibitors typically involves blocking the enzyme's ability to bind long-chain fatty acids or interfering with its active site where ATP and CoA are utilized to form the fatty acyl-CoA intermediate. Structurally, these inhibitors are often designed to mimic the natural substrates of FACL6 or the transition states of the reaction, enabling them to bind with high specificity and affinity to the enzyme. The use of FACL6 inhibitors is crucial for studying how fatty acid metabolism is regulated in different tissues and how disruptions in this process affect cellular functions. By modulating FACL6 activity, researchers gain insights into the dynamics of lipid utilization, storage, and the broader implications of fatty acid metabolism in maintaining cellular energy homeostasis and lipid signaling pathways. These inhibitors are valuable tools for understanding the intricate network of metabolic processes that are central to energy production and lipid regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound could induce DNA demethylation, resulting in the suppression of FACL6 gene transcription by unveiling binding sites for transcriptional repressors. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
By inhibiting histone deacetylase activity, Trichostatin A could promote a closed chromatin conformation around the FACL6 gene, leading to decreased transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may repress FACL6 expression by altering the differentiation status of cells and changing the repertoire of transcription factors that control the FACL6 promoter activity. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
This compound could selectively downregulate FACL6 by activating peroxisome proliferator-activated receptor alpha (PPAR-alpha), which may alter the transcription of genes involved in lipid metabolism, including FACL6. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
GW501516 might decrease FACL6 expression through activation of PPAR-delta, leading to a broad reprogramming of lipid metabolism genes and reducing the need for FACL6 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin could indirectly inhibit FACL6 expression by suppressing mTOR signaling, a pathway that controls the synthesis of numerous proteins, including those involved in lipid metabolism. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
As a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY2 94002 might downregulate FACL6 by disrupting the PI3K-AKT signaling pathway, which can control the transcription of various metabolic genes. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
This glucose analog could reduce FACL6 expression by inhibiting glycolysis and inducing cellular stress responses that prioritize energy conservation, leading to the suppression of energetically costly biosynthetic pathways. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib may downregulate FACL6 by inhibiting multiple kinases involved in growth signaling pathways, potentially leading to a decrease in lipid synthesis and storage. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin might repress FACL6 by inhibiting the activation of transcription factors such as NF-κB, which are involved in the expression of genes in inflammatory responses, including those related to metabolism. | ||||||