FACL6 Activators
Fatty Acid CoA Ligase 6 (FACL6), also known as ACSL6, is an enzyme that plays a pivotal role in the metabolism of long-chain fatty acids. It catalyzes the essential first step in the metabolic conversion of these fatty acids into their active form, acyl-CoA, thereby preparing them for subsequent degradation or incorporation into phospholipids and triglycerides. This biochemical reaction is crucial for numerous cellular processes, including lipid synthesis, energy production, and membrane architecture maintenance. The expression of FACL6 is tightly regulated and may be influenced by various dietary and environmental factors, reflecting the dynamic nature of cellular lipid requirements.
Certain chemicals, through distinct molecular pathways, can potentially increase the expression of FACL6, ensuring the cell's ability to adapt to alterations in fatty acid metabolism. For instance, polyunsaturated fatty acids like Eicosapentaenoic acid (EPA) can serve as substrates that heighten the demand for fatty acid activation, possibly triggering the upregulation of FACL6. Similarly, molecules that function as agonists for peroxisome proliferator-activated receptors (PPARs), such as Pioglitazone and Bezafibrate, may induce the transcription of FACL6 by activating these nuclear receptors that are instrumental in controlling genes pivotal for lipid processing. Compounds like all-trans retinoic acid, which are known to initiate gene transcription related to cell differentiation and growth, can also stimulate FACL6 expression to facilitate the increased turnover of fatty acids during these processes. Additionally, various nutritional components, including certain amino acids and vitamins like niacin, can influence FACL6 expression levels. These components might act as precursors or co-factors in metabolic pathways, signaling the cellular need for enhanced fatty acid metabolism and thus potentially increasing the expression of FACL6. The diverse nature of these activators underscores the complexity of lipid metabolism regulation and the adaptability of cellular enzymatic profiles in response to metabolic demands.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
EPA is an omega-3 fatty acid that may upregulate FACL6 expression by acting as a substrate that increases demand for fatty acid activation, particularly in the context of anti-inflammatory responses and to maintain membrane fluidity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone could induce FACL6 expression through its action as a PPAR-gamma agonist, thereby stimulating the transcription of genes that encode enzymes involved in the lipid oxidation pathway, including those involved in fatty acid uptake and activation. | ||||||
Dibenzoylmethane | 120-46-7 | sc-204719 sc-204719A | 25 g 100 g | $38.00 $52.00 | ||
Dibenzoylmethane, being structurally similar to curcumin, could stimulate the transcriptional activity of genes associated with fatty acid metabolism, potentially leading to an upsurge in FACL6 expression to facilitate the catabolism of fatty acids in response to increased cellular antioxidant activities. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate, as a PPAR-alpha agonist, may directly increase FACL6 expression to accelerate the beta-oxidation process, enhancing the catabolism of fatty acids in liver and muscle tissues, and promoting lipid homeostasis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
All-trans retinoic acid can stimulate FACL6 expression by activating nuclear receptors that trigger the transcription of genes necessary for the mobilization and metabolism of fatty acids, particularly during processes of cell differentiation and growth. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone acts as a PPAR-gamma agonist, and could thereby stimulate FACL6 expression to increase fatty acid storage in adipocytes and the utilization of these molecules within muscle cells, potentially balancing glucose and lipid levels in the blood. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid may trigger an upregulation of FACL6 expression by serving as a direct substrate for the enzyme, signaling a need for enhanced activation of fatty acids for membrane synthesis or storage in lipid droplets. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Theophylline could stimulate FACL6 gene expression as a response to its lipolytic activity, which raises free fatty acid levels in the plasma, thereby signaling a need for their activation and subsequent mitochondrial beta-oxidation. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Piceatannol has been shown to stimulate the expression of genes involved in the adipogenesis pathway, and could similarly upregulate FACL6 expression to enhance the conversion of fatty acids into forms suitable for storage or energy release. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Nicotinic Acid can induce FACL6 expression by serving as a precursor for NAD+, a coenzyme involved in redox reactions, which is essential for the dehydrogenase steps in fatty acid oxidation, signaling a requirement for increased fatty acid activation. | ||||||