ESE-1 Activators
ESE-1 Activators are a class of compounds that enhance the functional activity of ESE-1 by acting on various cellular mechanisms. Forskolin, through the increase of cAMP, activates PKA which can phosphorylate and influence the transcriptional activity of ESE-1. This phosphorylation may enhance the binding of ESE-1 to DNA, facilitating its transcriptional efficacy. Epigallocatechin gallate and 5-Aza-2'-deoxycytidine reduce methylation of the ESE-1 promoter region, which may lead to augmented ESE-1 expression and subsequent transcriptional activity. Similarly, Sulforaphane, Trichostatin A, and Sodium butyrate, as HDAC inhibitors, increase histone acetylation, allowing for a more open chromatin structure and improved ESE-1 access to DNA, which enhances its transcriptional regulation capabilities.
Further, Retinoic acid can induce the expression of genes that act as co-factors or enhancers of ESE-1 activity, while Curcumin, by inhibiting NF-κB signaling, can reduce suppressive inflammatory signaling pathways that hinder ESE-1 activity. Resveratrol, through SIRT1 activation, can lead to deacetylation of histones and transcription factors, creating a conducive chromatin environment for ESE-1. Piceatannol and SP600125, by modulating kinase activities, indirectly influence the transcriptional programs that ESE-1 is a part of, enhancing its transcriptional output. Lithium chloride's inhibition of GSK-3 may also contribute to the stabilization of transcription factors or co-activators that enhance ESE-1's transcriptional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Adenylyl cyclase activator that increases intracellular cAMP levels, leading to PKA activation which can enhance ESE-1 activity by promoting phosphorylation and subsequent transcriptional activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Polyphenol that inhibits DNA methyltransferases, reducing methylation at the promoters of certain genes, potentially enhancing ESE-1 activity by increasing its accessibility to DNA. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
HDAC inhibitor which leads to a more acetylated and open chromatin structure, potentially enhancing ESE-1 binding to target DNA sequences and its transcriptional activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Activator of retinoic acid receptors which can upregulate gene expression; may enhance ESE-1 activity by increasing expression of genes that provide co-factors or facilitate ESE-1 DNA binding and function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Inhibitor of NF-kB signaling, which may lead to reduced competition for co-activators required for ESE-1 function, thereby enhancing ESE-1 transcriptional activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
SIRT1 activator that deacetylates histones and transcription factors, potentially enhancing ESE-1 activity by modulating the chromatin state and transcription factor interactions. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Syk inhibitor that can alter signaling pathways, leading to transcriptional changes that include upregulation of genes that synergize with ESE-1, enhancing its functional activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor that increases acetylation of histones, potentially enhancing ESE-1 activity by improving the accessibility of ESE-1 to its target genes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
GSK-3 inhibitor that can lead to the stabilization of β-catenin, which may interact with ESE-1 and enhance its transcriptional activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor that reduces DNA methylation, potentially enhancing ESE-1 activity by increasing gene expression of ESE-1 or its co-factors. | ||||||