Embigin Inhibitors
Chemical inhibitors of Embigin can modulate its function through various cellular signaling pathways. Phloretin, for instance, targets glucose transporters, which are associated with Embigin's role in glucose uptake. By inhibiting these transporters, Phloretin can directly inhibit the facilitative function of Embigin in glucose metabolism. Similarly, Genistein, an isoflavone known for its inhibition of tyrosine kinases, can alter the tyrosine phosphorylation-dependent signaling pathways that Embigin is involved with, particularly those related to integrin signaling. This can lead to a functional inhibition of Embigin's role in these pathways. Another inhibitor, PD98059, specifically intervenes in the MAPK/ERK pathway by inhibiting MEK, thereby potentially inhibiting Embigin's function in cell adhesion and signaling. LY294002 and Wortmannin, both inhibitors of PI3K, can downregulate the PI3K/AKT pathway, where Embigin might have a role, thus functionally inhibiting its activity.
Furthering this approach, SB203580 and SP600125 inhibit p38 MAP kinase and JNK, respectively, both of which are involved in stress responses and inflammation, processes where Embigin could play a part. By inhibiting these kinases, SB203580 and SP600125 can disrupt the stress response signaling pathways that involve Embigin. U0126, which inhibits MEK1/2, and PP2, an inhibitor of Src family tyrosine kinases, both target kinases that are critical to the signaling cascades that Embigin associates with. Thus, they can interfere with Embigin's role in these pathways. Additionally, AG490, targeting JAK2, and Dasatinib and Gefitinib, both broad-spectrum tyrosine kinase inhibitors, can interrupt various signaling pathways including those related to JAK/STAT and EGFR, where Embigin could be implicated. By doing so, these inhibitors disrupt the functional activity of Embigin within these complex signaling networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $63.00 $250.00 | 13 | |
Phloretin is a dihydrochalcone, a type of polyphenol. It inhibits various glucose transporters, which can indirectly inhibit Embigin as Embigin is associated with glucose transport and modulation of GLUTs. By inhibiting GLUTs, Phloretin can inhibit Embigin's function in facilitating glucose uptake. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone that primarily inhibits tyrosine kinases. Embigin is known to interact with integrins and modulate signaling pathways involving tyrosine phosphorylation. By inhibiting tyrosine kinases, Genistein can disrupt these pathways, leading to the inhibition of Embigin's associated signaling functions. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a specific inhibitor of mitogen-activated protein kinase kinase (MEK), which is involved in the MAPK/ERK pathway. Embigin has been implicated in cell adhesion and signaling pathways that include ERK. By inhibiting MEK, PD98059 can suppress ERK activation, thus inhibiting Embigin's function in these pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K), which are upstream regulators of the AKT signaling pathway. Embigin has been shown to be involved in signaling pathways that mediate cellular processes regulated by PI3K/AKT. Inhibition of PI3K by LY294002 can thus functionally inhibit Embigin's role in these processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase, part of a signaling pathway that regulates pro-inflammatory cytokines and stress responses. Embigin is implicated in cellular processes modulated by p38 MAPK. Inhibiting p38 MAPK with SB203580 can inhibit Embigin's function in cellular stress response pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. Given Embigin's association with signaling pathways that involve PI3K, inhibition of PI3K activity by Wortmannin can lead to the functional inhibition of Embigin's role in these signaling pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is involved in cellular stress and inflammatory responses. Embigin is a protein that may be involved in these responses. By inhibiting JNK, SP600125 can functionally inhibit the role that Embigin plays in cellular stress response pathways. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. Embigin is known to be associated with integrin-mediated signaling, which can involve Src kinases. By inhibiting Src kinases, PP2 can inhibit signaling pathways that involve Embigin, leading to its functional inhibition. | ||||||
AG-490 | 133550-30-8 | sc-202046C sc-202046A sc-202046B sc-202046 | 5 mg 50 mg 25 mg 10 mg | $82.00 $323.00 $219.00 $85.00 | 35 | |
AG490 is a tyrosine kinase inhibitor that specifically targets JAK2. Embigin is implicated in signaling pathways that could be regulated by JAK/STAT signaling. By inhibiting JAK2, AG490 can inhibit the downstream signaling pathways in which Embigin is involved, leading to its functional inhibition. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor with activity against Src family kinases and other kinases. By inhibiting Src and other kinases, Dasatinib can disrupt signaling pathways that Embigin may modulate, leading to its functional inhibition. | ||||||