Elastase-3 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sivelestat | 127373-66-4 | sc-203938 | 1 mg | $105.00 | 2 | |
Sivelestat, a neutrophil elastase inhibitor, directly targets elastase-3. By binding to the active site, it inhibits elastase activity, preventing proteolytic degradation of elastin and other substrates. This direct inhibition of elastase-3 preserves tissue integrity and prevents elastin breakdown, offering therapeutic potential in conditions involving excessive elastase activity. | ||||||
Pefloxacin mesylate dihydrate | 149676-40-4 | sc-204838 | 5 g | $62.00 | ||
Pefloxacin, a fluoroquinolone antibiotic, indirectly modulates elastase-3. By inhibiting bacterial DNA gyrase, it reduces neutrophil recruitment and elastase release. This indirect inhibition of elastase-3 activity can attenuate elastin degradation, preserving tissue integrity in conditions involving bacterial infection and inflammation. | ||||||
GW311616 hydrochloride | 197890-44-1 | sc-506571 | 1 mg | $94.00 | ||
GW311616A, a matrix metalloproteinase (MMP) inhibitor, indirectly modulates elastase-3. By inhibiting MMPs, it prevents elastin degradation and reduces elastase release. This indirect inhibition of elastase-3 activity can contribute to maintaining tissue structure in conditions involving MMP-mediated extracellular matrix remodeling. | ||||||
Dapsone | 80-08-0 | sc-203023 sc-203023A | 1 g 5 g | $19.00 $32.00 | 2 | |
Dapsone, an anti-inflammatory agent, indirectly modulates elastase-3. By reducing neutrophil activation, it limits elastase release and activity. This indirect inhibition of elastase-3 helps preserve tissue integrity in inflammatory conditions, preventing excessive elastin degradation and associated pathological changes. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein, a flavonoid, indirectly modulates elastase-3. By inhibiting inflammatory pathways, it reduces neutrophil activation and elastase release. This indirect inhibition of elastase-3 activity can mitigate elastin degradation, offering potential therapeutic benefits in conditions associated with inflammation and excessive protease activity. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide, a sesquiterpene lactone, indirectly modulates elastase-3. By inhibiting NF-κB activation, it reduces neutrophil recruitment and elastase release. This indirect inhibition of elastase-3 activity can attenuate elastin degradation, providing therapeutic potential in inflammatory conditions involving NF-κB-mediated pathways. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $82.00 $306.00 | 4 | |
Nafamostat, a serine protease inhibitor, directly targets elastase-3. By inhibiting serine proteases, including elastase, it prevents proteolytic damage. This direct inhibition of elastase-3 activity preserves tissue integrity, making nafamostat a potential therapeutic option in conditions associated with excessive serine protease activity, including elastase-3. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $112.00 $408.00 $3000.00 | 51 | |
Aprotinin, a protease inhibitor, directly targets elastase-3. By forming a reversible complex with elastase, it inhibits its proteolytic activity. This direct inhibition of elastase-3 helps preserve tissue integrity by preventing excessive elastin degradation. Aprotinin's inhibitory action on elastase-3 makes it a potential therapeutic option in conditions associated with protease-mediated tissue damage and inflammation. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen, a glutathione peroxidase mimic, indirectly modulates elastase-3. By reducing oxidative stress, it limits neutrophil activation and elastase release. This indirect inhibition of elastase-3 activity can attenuate elastin degradation, offering potential therapeutic benefits in conditions involving oxidative stress and excessive protease activity. | ||||||