Molecular structure of Sivelestat, CAS Number: 127373-66-4
Sivelestat (CAS 127373-66-4)
See product citations (2)
Alternate Names:
Elastase Inhibitor IV
Application:
Sivelestat is an inhibitor of elastase
CAS Number:
127373-66-4
Purity:
≥95%
Molecular Weight:
434.46
Molecular Formula:
C20H22N2O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Sivelestat displays >100-fold greater selectivity over pancreas elastase (IC50 = 5.6 µM). Sivelestat does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM. Sivelestat effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability. Sivelestat is also reported to inhibit mast cell Stat6-protease.
Sivelestat (CAS 127373-66-4) References
1. Suzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768. 2. Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.Inhibitor of:
C1r, cathepsin D, ChM-1, EG210155, Elastase-B, Granzyme, granzyme F, Klkb21, Klkb22, Mast Cell Chymase, Mast Cell Protease 2, MIF, Neutrophil Elastase, PI-9, PLC γ2, PR3, PRSS16, PRSS35, PRSS44, Prss47, PRSS51, Semenogelin-2, SerpinA3a, SerpinA3b, SerpinA3c, SerpinA3f, SerpinA3j, SerpinB11, Serpinb3c, Serpinb3d, SerpinB6B, SPINK6, T Neutrophil, TMPRSS11B, TMPRSS5, TPSB1, TPSB3, Tryptase γ, and UBE2D1.Activator of:
C9, CPA1, FAM194B, HSBP1L1, KLK5, MAN2B1, Mucin 19, PRSS35, SerpinA1a, TMPRSS11F, TMPRSS13, and TMPRSS5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sivelestat, 1 mg | sc-203938 | 1 mg | $105.00 |